摘要
目的：检测大肠癌 ICAM-1的表达探讨其与临床病理因素的关系。方法：应用免疫组织化学方法（ SABC法），采用 ICAM-1单克隆抗体测定 55例病理证实的大肠癌标本及 8例大肠腺瘤标本中 ICAM-1的表达。结果：大肠癌 ICAM-1阳性 41例，表达率 75％高于大肠腺瘤，差异显著（ P< 0.05） ;发生淋巴结转移的大肠癌 ICAM-1表达率高于未发生转移的大肠癌，差异显著（ P< 0.05），比较未发生转移的大肠癌与大肠腺瘤 ICAM-1的表达则无显著性差异。结论：大肠癌 ICAM-1的过度表达与淋巴结转移密切相关。
Objective： This study was designed to determine the expression of ICAM-1 in colorectal cancer and its clinical significance. Methods： The expression of ICAM-1 in 55 samples of colorectal carcinoma and 8 samples of adenomas were invested using immunohistochemical staining. Results： There were 41 positive cases in 55 colorectal cancer samples. The positive rate of ICAM-1 in colorectal cancer was significantly higher than that of adenomas（ P< 0.05） , ICAM-1 in colorectal cancer was significantly correlated with lymph node metastasis. However， there was no significantly difference in ICAM-1 expression between adenomas and colorectal cancer without lymph node metastasis. Conclusion： Over-expression of ICAM-1 was significantly related to lymph node metastasis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2001年第3期311-313,共3页
Chinese Journal of Cancer
