摘要
目的：探讨进展期胃癌手术切除后行 43℃顺铂、丝裂霉素溶液腹腔灌注治疗效果。方法：将 64例进展期胃癌患者随机分为灌注组和非灌注组，每组 32例，灌注组用 43℃顺铂，丝裂霉素腹腔灌注化疗作观察组。非灌注组 32例为对照组，并作术后随访 2年的疗效比较。结果：观察组 1、 2年生存率分别为 96.32％、 82.78％，对照组依次为 83.05％、 49.83％，（ P=0.0433）；观察组 1、 2年腹腔转移率分别为 28.12％、 40.62％，对照组为 37.5％、 68.75％，（ P=0.0238），毒副作用两组比较无明显差异（ P=0.2437）。结论：进展期胃癌手术加腹腔温热灌注化疗可以提高近期疗效。
Objective： This study was designed to evaluate the curative effect of resected advanced gastric carcinoma treated with 43℃ cisplatin and mitomycin C solution intraperitoneal perfusion chemotherapy. Method： The advanced gastric carcinoma patients(64 cases) were divided into observation group and control group. The observation group(32 cases) was treated with 43℃ cisplatin and mitomycin C solution intrapertonal perfusion chemotherapy. The control group(32 cases) was treated without intraperitoneal perfusion chemotherapy. The follow-up survey was compared after the treatment between two groups. Result： The one and two years survival rates were 96.32％ ,82.78％ and 83.05％ , 49.83％ respectively in the two groups. The two years survival rates in the observation group is higher than that in the control group(P=0.0433). One and two years abdominal metastasis rate were 28.12％ , 40.62％ and 37.5％ , 68.75％ respectively in the two groups. The two years abdominal metastasis rate in the observation group is lower than that in the control group (P=0.0238). There was no significant difference between two groups (P=0.2437). Conclusion： The curative effect in the near future can be improved in advanced gastric carcinoma treated by operation and intraperitoneal perfusion chemotherapy.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2001年第3期298-300,共3页
Chinese Journal of Cancer
