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急性冠脉综合征患者心率减速力测定的预测价值及临床意义 被引量:2

The clinical significance and predictive value of deceleration capacity of rate in acute coronary syndrome patients
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摘要 目的 通过对急性冠脉综合征(ACS)患者心率减速力(DC)特点研究,探讨DC对ACS高危患者的预测价值及临床意义.方法 选择100例ACS患者为ACS组,50例稳定型心绞痛(SAP)患者为SAP组,50例造影正常者为对照组.所有入选者均行24h动态心电图检查,将24h动态心电图经120 Hz数字化自动处理系统转换为以心动周期R-R值为纵坐标的序列图,筛选出减速周期,以选中的减速点为中心计算出X(0)、X(-1)、X(-2)、X(1),再经过公式DC(ms)=[X(0)+X(1)-X(-1)-X (-2)]×1/4,计算机自动测定DC.结果 ACS组患者异常DC的发生率明显高于SAP组(P<0.05)及正常对照组(P<0.01);ACS组患者的DC值明显低于SAP组(P<0.05)及正常对照组(P <0.01).结论 ACS患者的DC减弱.DC值可以直接反映冠心病患者的病变不稳定状态,病情愈严重,迷走神经的保护作用愈低,猝死风险愈高. Objective By studying the prediction of acute coronary syndrome(ACS) patients at high risk,to discuss the value and clinical significance of the heart rate deceleration force(DC).Methods 100 ACS patients (ACS group) were enrolled,patients with stable angina pectoris were 50 (SAP group) and normal human controls were 50.All patients were underwent 24 hour dynamic electrocardiogram.The 24 hour dynamic electrocardiogram were converted to system diagram using the heartbeat cycle R-R sequence as ordinate by digital automatic processing of 120 Hz,and the deceleration period was screened out,X(0),X(-1),X (-2),X (1)were calculated using the deceleration point as the center,then the DC by the formula of DC(ms)=[X(0)+X(1)-X(-1)-X(-2)]×1/4 was calculated automatically.Results The DC was significantly higher in the ACS group than that in SAP group (P<0.05) and normal control group (P<0.01).Conclusion The DC decreased in ACS patients.The value of DC can directly reflect the unstable state in patients with coronary heart disease.The illness is more serious,the protective effect of vagus nerve is lower,the risk of sudden death is higher.
出处 《中国心血管病研究》 CAS 2014年第4期313-315,共3页 Chinese Journal of Cardiovascular Research
关键词 急性冠脉综合征 心率减速力 动态心电图 Acute coronary syndrome The heart rate deceleration force 24 hour dynamic electrocardiogram
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  • 1Mehra R. Global public health problem of sudden cardiac death [ J ]. Journal of Electrocardiology ,2007,40 ( 6 ) : S118-S122.
  • 2Wessel N, Dash S, Kurths J, et al. Asymmetry of the acceleration and deceleration capacity of heart rate is strongly dependent on vcntricular premature complexes [ J ]. Biomed Tech ( Berl ), 2007,52 (3) :264-266.
  • 3Kantelhardt JW, Bauer A, Schumann AY, et al. Phase-rectified signal averaging for the detection of quasi-periodicities and the prediction of cardiovascular risk [ J]. Chaos ,2007,17 (3) : 15-112.
  • 4Gruberg L, Dagas G, Mehran R, et al. Clinical outcome follow- ing percutaneous coronary interventions in patients with chronic renal failure.Catheter Cardiovasc Interv, 2002,55 : 66-72.
  • 5Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death ,cardiovascular events,and hospitalization. N Engl J Med,2004,351 : 1296-1305.
  • 6Widimsky P, Rychlik I. Renal disease and acute coronary syn- drome. Heart, 2010,96 : 86-92.
  • 7Parikh PB, Jeremias A, Naldu SS, et al. Impact of severity of renal dysfunction:clinical characteristics in patients with ad- vanced chronic kidney disease, on dialysis,and without chronic kidney disease. A collaborative project of the United States Renal Data SysterrdNatinal Institutes of Health and the National Registry of Myocardial Infarction. Am Heart J, 2012,163 : 399-406.
  • 8Kantelhardt JW, Bauer A, Schumann AY, et al. Phase-recti- fiedsignal averaging for the detection of quasi-periodicities and the pre-diction of cardiovascular risk. Chaos, 2007,17 : 15-112.
  • 9Kurata C, Uehara A, Sugi T, et al. Cardiac autonomic neuropa- thy in patients with chronic renal failure on hemodialysis. Nephron, 2000,84 : 312-319.
  • 10Lewek J, Wranicz JK, Uzik P, et al. Clinical and electrocardiographic covariates of deceleration capacity in patients with ST-segment elevatiom myocardial infarction. Cardiol J, 2009,16 : 528-534.

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  • 1DiFrancesco D. Characterization of single pacemaker channels in- cardiac sino-atrial node cells. Nature, 1986,324 : 470-473.
  • 2Manz M, Reuter M, Lauck G, et al. A single intravenous dose of ivabradine, a novel If inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction. Cardiology, 2003,100: 149-155.
  • 3Savelieva I, Camm AJ. If inhibition with ivabradine: electrophysi- ological effects and safety. Drug Saf,2008,31:95-107.
  • 4Lappegard KT, Nordmo E. Ivabradine and nightmares: a previ- ously unreported adverse reaction. Eur J Clin Pharmacol, 2011,67: 1313-1314.
  • 5Fox K, Ford I, Steg PG, et al. Rationale, design, and baseline characteristics of the Study assessinG the morbidity-mortality benefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIFY trial) : a randomized, double -blind, placebo-controlled trial of ivabradine in patients with stable coro- nary artery disease without clinical heart failure. Am Heart J, 2013,166 : 654-661.
  • 6Jouven X, Empana JP, Escolano S, et al. Relation of heart rate at restand long-term (>20 years) death rate in initially healthy middle-agedmen. Am J Cardiol, 2009,103:279-283.
  • 7Siasos G, Tousoulis D, Athanasiou D, et al. Novel risk factors relatedto stableangina. Curr Pharm Des,2013,19:1550-1561.
  • 8Tardif JC, Ponikowski P, Kahan T, et al. Efficacy of the I(f) cursent inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy; a 4 month, randomized placebo-controlled trial. Eur Heart J, 2009,30 : 540-548.
  • 9Canet E, Lerebours G, Vilaine JP. Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine. Ann N Y Acad Sci,2011,1222:90- 99.
  • 10Steg P, Hamon M, Schiele F, et al. Safety of intravenous ivabradine in acute ST-Segment elevation myocardial infarction patients treated with primary percutaneous coronary interven- tion: a randomized,placebo-controlled, double-blind, pilot study. Eur Heart,2013,2:270-279.

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