摘要
现已明确 ,心力衰竭时神经激素的持续剌激对心脏具有严重的损害作用。循环儿茶酚胺升高对心肌细胞产生直接的毒性作用、增加膜通透性和心肌纤维化 ,这些作用可引起细胞死亡。在心力衰竭治疗中常用的 β受体阻滞剂包括 :普萘洛尔、美托洛尔、比索洛尔、布新洛尔和卡维地洛。这些药物与血管紧张素转换酶抑制剂、洋地黄类和利尿剂联合应用。一般来说 β受体阻滞剂治疗心力衰竭的益处有 :改善症状 ,降低发病率、病死率 ,提高对住院的需要及生活质量。β受体阻滞剂能阻止和逆转左室重构 ,减少致死性心律失常和心源性猝死的危险。 β受体阻滞剂的严重不良反应有低血压、心脏传导阻滞、心动过缓和液体潴留。现有大量资料证明 β受体阻滞剂对心力衰竭治疗的有益作用 。
It is now clear that continued stimulation of the neurohormonal system in heart failure (HF) has serious deleterious effects on the heart. The increase of circulating catecholamines exerts direct toxic effect on cardiac myocytes, increases membrane permeability and myocardial fibrosis; lead to aggravation of HF. β blockers are commonly used in the treatment of HF including propranolol, metoprolol, bisoprolol, bucindolol and carvedilol. These drugs are used in combination with ACEIs, digitalis and diuretics. Generally, the benefits of β blockade therapy in HF include improving symptoms, decreasing morbidity, mortality, elevating need for hospitalization and quality of life. β blockade therapy arrests and reverts LV remodeling and improves the risk of life threatening arrhythmias and sudden cardiac death. A few serious adverse effects include hypotension, heart blocks, bradycardia and fluid retention. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第2期187-191,共5页
Academic Journal of Second Military Medical University
