摘要
红花资源丰富且有悠久的民间用药历史,为了寻找其活性成分,丰富红花化合物的类型,对红花的化学成分进行系统的研究.用体积分数75%乙醇提取红花,所得浸膏以水稀释,再以石油醚、氯仿、乙酸乙酯和正丁醇萃取,对氯仿和乙酸乙酯部分浓缩所得浸膏以各种硅胶柱色谱和分离纯化,利用溶解性、颜色反应等理化性质以及红外光谱、质谱及氢(1)核磁共振等波谱数据确定了所得物质的结构.从红花中分离并鉴定了3个化合物,分别为:3-(3′,4′-二甲氧基苯基)-7-羟基-8-(3-甲基丁基)-香豆素(1),1-(2-吡啶基)-3-戊酮(2),α-甲氧基苯乙酸-1-十一烷基十二烷酯(3).这3个化合物均为首次从该植物中分离得到.
Safflower carthamus is rich in resources and has a long medication history. To find the active ingredient and enrich the types of compounds, a systematic research on its chemical constituents were carried out. The chemical constituents of S. carthamus were extracted by 75% ethanol. The residue was suspended in water and then extracted successively with Petroleum ether, chloroform, ethyl acetate and n-butanol. Chloroform part and ethyl acetate part were isolated and purified by silica gel column chro- matography and recrystallization. Their structures were characterized by solubility, chromogenic reac- tion,infrared,mass spectrometry and 1H NMR. Three compounds including Coumarin, 3-（3t ,4C dime- thoxyphenyl） -7-hydroxyl -8-（3- methylbut-hyl） （1）, 3-Pentone, 1-（2-pyridinyl） （2）, Benzeneacetic acid, a-methoxy-l-undecyldodecyl ester（3） were isolated and identified. All of them were obtained from this plant for the first time.
出处
《武汉工程大学学报》
CAS
2014年第3期15-17,共3页
Journal of Wuhan Institute of Technology
关键词
红花
化学成分
分离纯化
香豆素
Safflower carthamus
chemical constituents
separation and purification ~ coumarin
