摘要
用硫代巴比妥酸法检测新生儿(24例)、青年(20～35岁,17例)、中年(36～53岁,25例)、老年(60～68岁,23例)健康人群血浆唾液酸含量,发现随着生物年龄的增长,血浆唾液酸含量呈阶梯形上升趋势。因此,血浆唾液酸有可能成为一项老化的指标。
The healthy donors were divided into four groups: the neonate, the youth (20—35 years), the middle age(36-53 years) and the old age (60-68 years). The blood of the first one (neonate) was collected from the umbilical cord and that of the others by the vein's puncture before food intake in the morning. Heparin sodium was used as an anticoagulant. The plasma was gather ed after centrifugation and the sialic acid (SA) was measured with the method of Aminnoff. The values of SA were 46.59±1.51, 72.64±1.57, 72.17±1.96 and 81.06±1.98mg/100ml (SA/plasma, mean±SE) in the neonate(n=24), youth(n=17), middle age(n=25) and old age group (n=23), respectively. The analysis of varia nce revealed that the plasma SA of the neonate group was the lowest (P<0.01) and the old age one, the highest (P<0.01). There was no diffe rence between the middle age and the youth group(P>0.05). It seemde that as the human being got old, the plasma SA increased, altthough from the youth to middle gae it kept the same, almost unchanged. Therefore, the SA content of the plasma cound probably be used as an objective index of human aging.
出处
《贵阳医学院学报》
CAS
1991年第4期319-321,共3页
Journal of Guiyang Medical College
关键词
唾液酸
血浆
衰老
sialic acid
plasma
aging
