摘要
目的 探讨合适的门脉局部给药治疗门脉高压症的途径。材料与方法 采用CCl4 诱发的鼠肝硬化门脉高压模型 ,DDPH[1 ( 2 ,6 二甲基苯氧基 ) 2 ( 3 ,4 二甲基苯乙氨基 )丙烷盐酸盐 ]分别从下腔静脉、门静脉、肝动脉和脾脏输入 ,比较 4种途径给药后门脉压 (PVP)、下腔静脉压 (CVP)、平均动脉压 (MAP)和心率 (HR)的变化情况。结果 DDPH门脉注入和肝动脉注入使PVP平均下降12 .73 %和 8.93 % ,二者无明显差别 ,明显高于下腔静脉注入 ,后者平均下降 2 .3 4 % ;经门脉注入和肝动脉注入使MAP、HR下降分别为 :5 .71%、0 .78%和 6.3 0 %、1.79% ,明显低于下腔静脉注入 ,后者使MAP下降 10 .45 % ,HR升高 4.16%。脾脏给药虽使PVP下降6.0 0 % ,与下腔静脉注入无差别 ,但其使PVP CVP下降 8.95 % ,与门脉及肝动脉给药无差别 ,明显高于下腔静脉给药 ,后者PVP CVP下降 2 .41%。结论 DDPH经肝动脉注入同样具有经门脉注入治疗门脉高压的优点 ,即降门脉压作用强 ,对全身血流动力学影响小。肝动脉植泵注入扩血管性降门脉压药物是临床上理想的药物治疗门脉高压的方法。
Objective To find out the appropriate routes for portal targeting infusion in treating portal hypertension.Materials and Methods Twenty eight cirrhotic rat models with portal hypertension induced by CCl 4 were divided into 4 groups, each group was injected with DDPH [1 (2,6 dimethylphenoxy) 2 (3,4 dime thoxyphenylamino) propane hydrochloride] via IVC, portal vein, hepatic artery or spleen respectively. The changes in portal vein pressure (PVP), IVC pressure (IVCP), mean artery pressure (MAP) and heart rate (HR) were observed and compared between each group.Results DDPH intraportal or hepatic artery injection induced a bigger drop in PVP and showed less effects on MAP and HR than intravenous injection did. A significant bigger drop in PVP CVP was seen in group via spleen administration than that in group via intravenous injection, although no difference in PVP decrease rate between intravenous injection and spleen injection was found.Conclusion For the treatment of portal hypertension, hepatic artery DDPH administration carries the same advantages as intraportal infusion has, i.e. a greater decrease in PVP, less effect on systemic hemodynamics. Hepatic artery infusion of vasodilation drugs via percutaneous port catheter system implanted in hepatic artery may be an ideal method for the treatment of portal hypertension.
出处
《临床放射学杂志》
CSCD
北大核心
2001年第1期70-72,共3页
Journal of Clinical Radiology
基金
卫生部资助课题!批文号 :98- 1 - 1 32
关键词
治疗
肝动脉给药
血流动力学
门脉高压症
Hypertension,portal vein Treatment Hepatic artery injection Hemodynamics DDPH
