摘要
目的 :探讨 Apo AI基因启动子多态性与 2型糖尿病 ( DM-2 )伴同冠心病 ( CHD)的关系。方法 :应用聚合酶链反应技术 ,对 3 0例正常对照者、3 0例 CHD患者和 3 1例 DM-2患者及 3 0例 DM-2合并 CHD患者 (合并组 ) ,进行了载脂蛋白 AI基因启动子 -78bp( G/ A) Msp-I酶切位点限制性片段长度多态性 ( RFL P)研究。结果 :等位基因 A在 DM-2组、CHD组、合并组与对照组比较均显著降低 ( 0 .1 61 ,0 .1 83 ,0 .0 83 ,0 .43 0 ) ,A基因频率 DM-2组比合并组稍高 ,但无显著性差异 ( P>0 .0 5 )。结论 :Apo AI基因多态性是 DM-2合并
Objective:To investigate ApoAI gene promoter polymorphism in Chinese and explore its relation to DM 2 complicated with CHD.Methods:The ploymerase chain reaction and the ploymorphic sites of ApoAI(Msp I) were used to examine.The samples from 31 patients with DM 2,30 patients with CHD,30 patients of DM 2 with CHD and 30 healthy individuals as control.Results:The frequencies of A allele were significanty decreased in DM 2,CHD,DM 2 with CHD.There were no significant differences between DM 2 and DM 2 with CHD.Conclusion:ApoAI gene polymorphism may be the genetic marker of the CHD with DM 2.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2001年第1期9-12,共4页
Journal of Zhejiang University(Medical Sciences)
关键词
Ⅱ型糖尿病
冠心病
载脂蛋白A-I
启动区
基因多态性
Type 2 Diabetes mellitius,non insulin dependent/compl
Coronary disease/compl
Apolipoprotein A I
Promoter regions (genetics)
