摘要
目的探讨IgM-RF、IgG-RF、IgA-RF的定量检测对提高类风湿关节炎(RA)早期诊断准确性、明确活动度的意义。方法选择2011年1月至2013年4月在天津市第一中心医院就诊的患者及健康体检者作为研究对象,根据患者的疾病类型分为未确诊关节病/关节炎组、确诊RA组、其他风湿免疫病组及正常人组,比较四组患者血清IgM-RF、IgG-RF和IgA-RF的水平、阳性率及随访结果。结果确诊RA组患者血清IgM-RF、IgG-RF和IgA-RF的阳性率及水平均显著高于其他三组(P<0.05);确诊为RA的患者中高活动度组患者血清IgM-RF、IgG-RF和IgA-RF的水平均显著高于其他三组(P<0.05);对未确诊关节病/关节炎组患者的随访发现,IgM-RF、IgG-RF及IgA-RF同时阳性对RF的确诊率为100%。结论 IgM-RF、IgG-RF、IgA-RF的定量检测对于提高RA早期确诊率、降低漏诊率、评估疾病活动度具有重要意义。
Objective To explore the clinical significance of ration detection of three kinds of rheuma- toid factors （RFs,including IgM-RF, IgG-RF and IgA-RF） for early diagnosis accuracy and identification of activity degree of rheumatoid arthritis（RA）. Methods Patients and healthy people who visited Tianjin First Central Hospital during Jan. 2011 and Apr. 2013 were selected as the research objects. By the disease type, the patients were divided into unconfirmed arthropathy/arthritis group, RA group, other immune diseases group and healthy group, the IgM-RF, IgG-RF and IgA-RF level, positive diagnosis rate and follow-up results of the four groups were compared. Results The serum positive rate and level of IgM-RF, IgG-RF and IgA-RF of RA group were significantly higher than the other three groups（ P 〈 0.05 ）. In RA group, IgM-RF, IgG-RF and IgA-RF levels of high activity group were significantly higher than other three groups （ P 〈 0.05 ）. Follow-up of arthralgia/arthritis group discovered that the simultaneous positive results of IgM-RF, IgG-RF and IgA-RF were 100% for RA diagnosis. Conclusion IgM-RF,IgG-RF and IgA-RF quantitative detection can improve the rate of RA early diagnosis, reduce missed diagnosis,which is of great significance for assess- ment of RF activity.
出处
《医学综述》
2014年第7期1296-1298,共3页
Medical Recapitulate
关键词
类风湿因子
类风湿关节炎
定量检测
Rheumatoid factors
Rheumatoid arthritis
Ration detection
