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补体系统与Alzheimer病(综述) 被引量：1

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摘要 研究表明 ,经典补体通路的全部补体成分、多种补体调节蛋白及其受体等均在Alzheimer病 (AD)脑内存在和上调表达 ,且与含Aβ的AD病理结构密切相关。经典补体通路在AD患者脑内的活化以及活化的补体成分与AD病理损害之间的高度相关性表明 ,补体系统可能参与了AD的脑内病理活动。
作者 祖衡兵 陈生弟
机构地区 上海医科大学附属金山医院神经科 上海第二医科大学附属瑞金医院神经科
出处 《中国神经免疫学和神经病学杂志》 CAS 2001年第1期56-58,共3页 Chinese Journal of Neuroimmunology and Neurology
关键词 补体 ALZHEIMER病 发病机制 病理
分类号 R749.160.2 [医药卫生—神经病学与精神病学]
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参考文献19

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同被引文献22

  • 1张可喜.日发现可能引发早老性痴呆症的酶.首都医药,2000,7(9):10-10.
  • 2Mann DM, Thaker U, McDonagh AM, et al. Deposition of tan in the brain in Alzheimer's disease is related to the amount of Abeta40 but not Abeta42 (43) deposits and the presence of apolipoprotein E epsilon4 allele[J ]. Neuropathol Appl Neurobiol,2002 Apr,28(2) : 148-149.
  • 3Fagan AM,Watson M, Parsadanian M, et al. Human and Murine ApoE Markedly Alters Abeta Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer' s Disease[ J ]. Neurobiol Dis,2002 Apr,9(3) :305-318.
  • 4Milanese C, Sehettini G. Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-piptides induced oxidative stress and reduces NF-kappaB activation[ J ]. Neurochein Int,2002 Jul,41(1) :43-54.
  • 5Phinney AL, Abramowski K, Sturchler-Pierrat C, et al. Cholinergic changes in the APP23 transgenic mouse nodel of cerebral amyloidosis [ J ]. J Neurosci, 2002 Apr 15,22 (8) : 3234-3243.
  • 6Giacobini E. Long-term stabilizing effect of cholinesterase inhibitors in Alzheimer treatment [ J ]. Rev Neurol(Paris), 2001,157Suppl 10:31.
  • 7王跃春,王子栋.c-fos过度表达与Alzheimer病[J].中国病理生理杂志,1999,15(1):83-86. 被引量：4
  • 8王建枝,I.Grundke-Iqbal,K.Iqbal.磷酸酶和糖苷酶对Alzheimer神经原纤维缠结的作用[J].中华神经科杂志,1999,32(4):205-207. 被引量：3
  • 9王建枝,Iqba.,IG.蛋白磷酸酯酶在Alzheimer氏病tau蛋白异常磷酸化中的作用[J].基础医学与临床,1999,19(4):74-78. 被引量：4
  • 10李玫,常晓兰,陶学训.Alzheimer's型老年性痴呆与tau蛋白异常修饰[J].汕头大学医学院学报,2000,13(1):73-75. 被引量：3

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中国神经免疫学和神经病学杂志
2001年 第1期

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