摘要
采用单盲、随机、自身交叉临床试验设计,比较毛冬青甲素与地高辛对8例纽约心脏协会心功能Ⅲ级的慢性充血性心力衰竭患者的运动耐量的影响。口服一周的毛冬毒甲索(120毫克,每日三次)能显著提高运动功量,从3502.17±1832.90焦耳(357±186.84公斤米)到5601.51±3232.10焦耳(57l±329.47公斤米)(P=0.0262)和运动耐量时间从192±79.105秒到260.875±98.835秒(P=0.037)。口服一周地高辛(0.25mg,每日一次)能显著提高运动功量从3938.71±3146.56焦耳(401.5±320.75公斤米)到5612.55±3660.89焦耳(572.125±373.18公斤米)(P=0.018)和运动耐量时间从194.875±107.98秒到263.825±106.755秒(P=0.01);两种药物之间提高运动功量及运动耐量时间无明显差异(P值分别为0.8785及1).结果表明,毛冬青甲索和地高辛有近似的提高运动耐量的作用.
The effects of Ilexonin A on exercise capacity were compared with those of digoxin in 8 patients with NYHA class III chronic congestive heart failure (CCHF) in a randomized single-blinded crossover clinical trial. A week of oral Ilexonin A therapy (l20mg, Tid) significantly improves exercise workload from 375±186. 84kg. m to 571±329. 47kg.m (P=0.0262) and exercise tolerance time from 192±79.105 seconds to 260.875±98.835 seconds (P=0.037). A week of oral digoxin therapy (0.25mg, qd) significantly improves exercise workload from 40l.5±320.75 kg.m (P=0.018) and exercise tolerance time from 194.875±107.93 seconds to 263.625±106.755 seconds (P=0.0l). There are no significant differences between two drugs in exercise workload and exercise tolerance time (P=0.8785 and P=l respectively). It is indicated that Ilexonin A and digoxin have similar effects on the improvement of exercise capacity.
关键词
心力衰竭
毛冬青甲素
地高辛
HEART FAILURE, CONGESTIVE/drug therapy
ILEXONIN A/therapeutic use
DIGOXIN/therapeutic use
EXERCISE TEST
