摘要
目的对肺结核住院患者临床资料进行分析,并对治疗方法和治疗后的病情转归进行归纳总结,为临床资料提供参考依据。方法回顾性分析医院2008年1月-2011年12月683例肺结核住院患者的临床资料、用药情况、合并症及随访1年的临床转归等,对患者抗结核药物耐药性、治疗后临床转归及相关因素,采用SPSS12.0进行分析。结果多药耐药是肺结核住院患者的特征表型,占9.22%;伴发糖尿病的肺结核患者,在抗结核给药相同前提下,胰岛素治疗组1个月内转阴率为87.50%,明显高于口服降糖药物组的53.27%,<20岁的青少年和>80岁的老年肺结核患者病死率最高,分别为5.48%和14.06%,两组病死率差异无统计学意义。结论根据抗结核药物耐药测试制定个性化治疗方案,有助于降低住院肺结核患者抗结核药物耐药率,合并糖尿病、心血管疾病等并发症影响肺结核患者抗结核治疗的临床转归及预后。
OBJECTIVE Analysis for pulmonary tuberculosis patients in our hospital was performed to study therapeutic methods and the prognosis ,so as to provide reference for clinic .METHODS From Jan .2008 to Dec . 2011 ,a total of 683 cases of smear positive pulmonary tuberculosis in our hospital were enrolled for retrospective analysis .Anti-tuberculosis drug resistance ,treatment outcome and related factors were analyzed by SPSS 12 .0 software .RESULTS Multidrug resistance was the characteristics of phenotype for hospitalized patients with pulmonary tuberculosis ,accounting for 9 .22% .In patients with diabetes tuberculosis ,in the same premise of anti-tuberculosis drug ,the effective rate of insulin treatment group in the first month was 87 .50% ,significantly higher than 53 .27% of oral hypoglycemic drug group ,the teen-agers in ＆lt;20 years old and elderly older than 80 years old patients with pulmonary tuberculosis had the highest case fatality rate ,accounting for 5 .48% and 14 .06% .but mortality had no sisnificont difference between the two groups .CONCLUSION Formulate individual-ized treatment plan according to test resistance of anti-tuberculosis drugs can reduce the anti-tuberculosis drug resistance rate in hospitalization patients with pulmonary tuberculosis .Combined with diabetes ,cardiovascular disease and other clinical complications will ffect the treatment outcome and of prognosis of pulmonary tuberculosis patients .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第7期1708-1710,共3页
Chinese Journal of Nosocomiology
基金
国家科技重大专项基金项目(2011ZX10004-901)
关键词
肺结核
住院
糖尿病
耐药性
药物不良反应
Pulmonary tuberculosis
Hospitalize
Diabetes
Drug resistance
Side effect
