摘要
目的 :建立氧氟沙星注射液的细菌内毒素检查法。方法 :根据中国药典 1995年版二部收载的细菌内毒素检查法的要求进行实验。结果 :将氧氟沙星注射液经 2倍稀释可消除干扰因素 ,用标示灵敏度为 0 .2 5Eu/ml的鲎试剂检测细菌内毒素是有效的。结论 :可用鲎试验法取代家兔法对氧氟沙星注射液进行热原检查。
OBJECTIVE:To establish the inspection method of endotoxin in ofloxacini injection.METHODS:The experiment is implemented according to the request of endotoxin inspection method collected in the 2nd book,China pharmacopeia,1995.RESULTS:The experiment showed that the interference elements can be excluded by diluting ofloxacini injection 2 times,and it is effective that endotoxin can be tested by amebocyte lysate with accuracy of 0.25Eu/ml.CONCLUSION:For daily pyragen test of ofloxacini injection,enotoxin inspection method can be used instead of dometic rabbit method.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第1期62-63,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
氧氟沙星注射液
细菌内毒素检查
干扰试验
ofloxacini injection,endotoxin experiment,interference experiment
