摘要
目的 :观察 70味珍珠丸对“血瘀”大鼠血液流变学的影响 ,了解其活血化瘀作用。方法 :ig 70味珍珠丸 ,并用冰水浴刺激和sc肾上腺素 ,制造大鼠“血瘀”模型 ,测定血液流变学各项指标。结果 :70味珍珠丸可明显降低“血瘀”大鼠低切变率下的全血粘度、全血还原粘度 (P <0 .0 5 )、红细胞聚集指数 (P <0 .0 5 ,P <0 .0 1)及红细胞压积 (P <0 .0 5 ) ;同时也有降低中、高切变率大鼠全血粘度、全血还原粘度、纤维蛋白原以及延长凝血时间和减少血小板数的趋势 (P >0 .0 5 )。另外不改变正常大鼠凝血酶原时间和出血时间。结论 :本品对“血瘀”大鼠可抑制红细胞聚集和凝固 ,降低血液粘稠度和浓度 ,具有一定的活血化瘀作用。但不影响正常的凝血功能。
OBJECTIVE:To obeserve the effect of RNSP on blood rheology in increased blood viscosity rat and analysis its machanism that is related to cerebral vascular.METHOD:The animal model of acute blood stagnation was formed quickly in rats by injected Adrenaline and cold water stimulation,the parameter of blood rheology were measured.RESULTS:RNSP 0.5g/kg and 1g/kg markedly decreased whole blood viscosity(η b) and whole blood reduced viscosity(η r) at shear rates of 10s -1 ,50s -1 and 120s -1 ,specially at low shear rate,deduced the aggregation inder of RBC(AI) and hemotocrit(Hct).At the same time,no effects on bleeding time and clotting time were observed.The effect of RNSP 1g/kg is similar to that of injectio salvia miltiorrhiza(SM).CONCLUSION:RNSP had the inhibition effect on the aggregate and coagulate function of Red blood cells,and would decrease the blood viscosities.It promoted the blood circulation to remove blood stasis,but had no effect on bleeding time and clotting,in normal animals.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第1期15-17,共3页
Chinese Journal of Modern Applied Pharmacy
基金
该研究内容系国家中医药管理局科研项目!课题合同号 :97M0 0 3
