摘要
目的 观察树脂型和玻璃离子型两种窝沟封闭剂对第一恒磨牙的防龋效果,以期为儿童龋病预防工作提供依据.方法 采用随机、空白对照、受试者单盲、为期2年的研究设计,选取至少有1颗第一恒磨牙有深窝沟或非成洞龋的7～9岁儿童419人（共计664颗第一恒磨牙）为研究对象,采用分层随机的方法将入选儿童分为3组,R组（136人,219颗牙）使用光固化树脂型封闭剂（Helioseal F）封闭;G组（130人,218颗牙）使用光固化玻璃离子型封闭剂（FUJIⅦ）封闭;N组（153人,227颗牙）为空白对照组.在封闭后6、12及24个月时回访,观察3组儿童第一恒磨牙新生龋的发病情况,采用卡方检验分析3组间龋病发病率的差异,使用广义估计方程分析不同干预方式、纳入研究的牙位分布及封闭前窝沟状况对龋病发病率的影响.结果 R组2年龋病发病率为3.0％（6/197）,G组为6.7％（13/193）,N组为14.7％（29/197）,3组间差异有统计学意义（P＜0.05）,R组和G组间差异无统计学意义（P＞0.05）.2年回访时与N组相比,使用树脂型封闭剂预防了79.6％的龋齿,使用玻璃离子型封闭剂预防了54.4％的龋齿.结论 树脂型封闭剂和玻璃离子型封闭剂均能有效预防第一恒磨牙龋病的发生,两种材料的防龋效果相似.
Objective To evaluate the effectiveness of resin-based sealants and glass ionomer sealants on caries prevention in the first permanent molars.Methods A randomized controlled,examiner-blinded,2-year clinical trial with parallel groups was conducted.A total of 419 children（664 first molars） who had at least one sound first permanent molar with deep fissures or fissures with signs of non-cavitated lesions were recruited.They were randomly allocated into three groups.Helioseal F,a light-cured resin-based sealants was used in group R （136 children with 219 first molars）.FUJI Ⅶ,a light-cured glass ionomer sealants was used in group G（130 children with 218 first molars） and group N （153 children with 227 first molars） was blank control.Follow-up examinations were conducted at 6,12,and 24 month after sealing to examine the sealants retention and caries incidence.Chi-square test was used to compare the differences of caries incidence among the 3 groups.Generalized estimating equations （GEE） was used to analyze the effective factors of caries incidence.Results During the 2-year follow-up period,3.0％（6/197） of the teeth in group R,6.7％ （13/193） of the teeth in group G,and 14.7％ （29/197） of the teeth in group N were diagnosed as having developed a cavitated lesion.The difference in the incidence of caries among the three groups was significant （P ＜ 0.05）.No significant difference in caries incidence was found between group R and group G （P ＞ 0.05）.The tooth-level preventive fractions were 79.6％ for resin-based sealants and 54.4％ for glass ionomer sealants,respectively.Conclusions Both resin-based sealants and glass ionomer sealants can effectively prevent the incidence of caries in the first permanent molars.The two sealants have similar caries prevention effect
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2014年第4期199-203,共5页
Chinese Journal of Stomatology
基金
中华口腔医学会与中国牙病防治基金会联合资助窝沟封闭科研项目（2009-01）
关键词
龋齿
窝沟封闭剂
第一恒磨牙
防龋效果
Dental caries
Pit and fissure sealants
The first permanent molars
Caries prevention effect
