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贵州省汉族、苗族、布依族人群载脂蛋白M与血脂水平相关性研究

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摘要 目的了解贵州省汉族、苗族、布依族人群载脂蛋白M(ApoM)与血脂水平的关系。方法 (1)应用ABC双抗夹心法检测血浆ApoM含量。(2)用自动生化仪检测血清中甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果 (1)3个民族人群的血浆ApoM含量与TG、TC均呈显著负相关。(2)汉族人群ApoM含量明显低于苗族和布依族人群,TC含量明显高于苗族和布依族人群。结论 ApoM含量改变影响脂质代谢,血浆ApoM含量降低使TG、TC水平升高。
作者 王晓琼
出处 《卫生职业教育》 2014年第7期137-138,共2页 HEALTH VOCATIONAL EDUCATION
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参考文献9

  • 1Xu N, Dahlbeck B. A novel human apolipoprotein(apoM)[J]. Biol Chem, 1999,274(44):31286-31290.
  • 2Symi Richter, David Q,Shih E,et al. Regulation of apolipoprotein M gene expressed by MODY3 gene hepatocyte nuclear factor-lalpha:haploin- stdiciency is associated with reduced serum apolipoprotein M levels[J].Di- abetes, 2003,52(12) : 2989-2995.
  • 3Xu N,Hurtig M,Zhang X Y, et al. Transforming growth Factor- beta down regulates apolipoprotein M in HepG2 cells[J].Biochim Biophys Acta, 2004(3) : 33-37.
  • 4Wolfram C,Stoffel M. Apolipoprotein M is required for prebeta-HDL formation andcholesterol efllux to HDL and protects against atherosclerosis [J]. NatMed, 2005,11(4) :418-422.
  • 5Christoffersen C, Dahlback B, Nielseh L B. Apolipoprotein M progress in understanding its regulation and metabolic functions [J]. Scand J Clin Lab Invest, 2006,66(7) :631-637.
  • 6Christoffersen C,Nielsen L B, Axler O, et al. Isolation and characteri- ration of b,man apoli-poprotein M-containing lipoproteins[J]j Lipid Res, 2006,47(8) : 1833-1843.
  • 7莫翼军,黄韵祝,黄健.贵州省汉族、苗族及布依族人群载脂蛋白M基因多态性与血脂的相关性[J].贵阳医学院学报,2011,36(5):477-480. 被引量:2
  • 8Xu N,Nilsson-Elde P, Ahren B. Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects [J]. J Nutr Biochem, 2004,15(10) :579-582.
  • 9荆朝辉,张晓膺,NING Xu,罗光华,董选.2型糖尿病患者中载脂蛋白M与脂蛋白a、载脂蛋白AI的关系研究[J].现代医学,2006,34(2):96-100. 被引量:11

二级参考文献24

  • 1Guanghua L, Xiaoying Z, Nilsson-Ehle P, et al. Apolipoprotein M[J]. Lipids in Health and Disease,2008(3) :21.
  • 2Ahnstrom J, Axler O, Jauhiainen M, et al. Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies [ J ]. Journal of Lipid Research,2008 (9) :1912 -1917.
  • 3Hu YW, Zheng L, Wang Q. Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes [J]. Biochimicaet Biophysica Acta,2010(2) :100 -105.
  • 4Ahnstrom J, Gottsater A, Lindblad B, et al. Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms [ J ]. Clinical Biochemistry,2010(4 -5) :407 -410.
  • 5Dullaart RP, Plomgaard P, de Vries R, et al. Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness [ J ]. Clinica Chimica Acta( international journal of clinical chemistry), 2009 (1 -2) :129 -133.
  • 6Niu N, Zhu X, Liu Y, et al. Single nueleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apo M) confer the susceptibility to development of type 2 diabetes in Han Chinese [ J ]. Diabetes Metab Res Rev,2007 (1) :21 -25.
  • 7Lu Z, Luo GH, Zhang XY, et al. Determination of single- nucleotide polymorphism in the proximal promoter region of apolipoprotein M gene in coronary artery diseases [ J ]. International Journal of General Medicine, 2009 ( 2 ) : 177 - 182.
  • 8Wolfrum C, N Poy M, Stoffel M. Apolipoprotein M is required for prel3-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis[ J]. Nature Medicine, 2005 (4) :418 - 422.
  • 9Christoffersen C, Nielsen LB, Olofaxler, et al. Isolation and characterization of human apolipoprptein M-containing lipoproteins [ J ]. Joumal of Lipid Research, 2006 (47) : 1833 - 1843.
  • 10Dahlback B, Nielsen ,L B. Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation[J]. Cellular&Molecular Life Sciences,2009 (66) :559 -564.

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