摘要
目的 研究移植前预致敏状态对移植肾生存率的影响。方法 分析我院 175例次再次肾移植的 1、2、3年移植肾存活率 ,及肾移植受者术前血清群体反应抗体 (PRA )水平对移植肾存活率的影响。结果 再次移植 1、2、3年的移植肾存活率分别为 6 0 .2 %、48.5 %和 34 .4% ,明显低于首次移植的 82 .7%、71.8%和 5 0 .6 %。在近 3年32 0例淋巴毒交叉配型结果 (CDC)≤ 5 %的患者中 ,有 40例患者血清的 PRA≥ 5 0 % ,其中 14例为首次移植 ,移植肾的一年存活率为 79.5 % ,2 6例为再次移植 ,存活率为 6 1.5 % (P<0 .0 5 )。而 2 80例血清 PRA <5 0 %的患者移植肾一年存活率 ,首次移植者为 89.3% ,再次移植者为 79.2 % (P<0 .0 5 )。结论 本研究结果表明 ,移植前患者的 PRA水平以及再次移植是影响移植肾存活率的重要因素。
Objective To study the effect of presensitization condition on renal graft survival rate.Methods Analyzing the 1,2,3 years renal graft survival rate in 175 retransplant recipients and the effect of panel reactive antibody (PRA) level on the outcome of renal transplantation.Results 1,2 and 3 years renal graft survival rate in retransplant recipients were 60.2%,48.5% and 34.4% respectively versus 82.7%,71.8% 50.6% in first transplant recipients.Among 320 recipients with CDC≤5%,there wre 40 recipients with serum PRA level≥50%,14 cases of them were first transplant with 79.5% one year graft survival rate versus 61.5% (P<0.05) in 26 cases retransplant.The one year graft survival rate of first transplant and retransplant in 280 recipients with PRA<50% were 89.3% and 79.2% respectively (P<0.05).Conclusions PRA level and retransplant are important factors that affecting the outcome of renal transplantation.
出处
《北京医学》
CAS
北大核心
2001年第1期6-7,共2页
Beijing Medical Journal
