摘要
目的 :研究扶正抗白冲剂 (FZKBG)对实验小鼠免疫功能及生存期的影响 ,探讨FZKBG治疗微小残留白血病 (MRL)的机理。方法 :接种L72 12 细胞 1× 10 6/只 ,接种后第 3天腹腔注射环磷酰胺 2 50mg/kg ,造成MRL模型小鼠 ,分成模型对照组、模型给药组 ,另设正常对照组、正常给药组 ,分别观察各组小鼠淋巴细胞亚群 (CD3+、CD4 +、CD8+)改变 ,免疫器官病理变化和生存期。结果 :与模型组比较 ,FZKBG能明显提高正常小鼠和MRL模型小鼠CD3+、CD4 +、CD8+的百分比和绝对值 (P <0 0 5,P <0 0 1)。且明显延长MRL模型小鼠存活期 ,延长生命率 2 9 6%～ 60 4 %。结论 :FZKBG能明显延长MRL模型小鼠存活期 ,其机理可能是通过提高MRL模型小鼠的免疫功能 。
Objective: To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and study its mechanism. Methods: MRL model mice were established by hypodermic inoculation with L 7212 cells following intraperitoneal injection of cytoxan (CTX)25 mg/kg 3 days later, and divided into the control group and FZKBG group. The changes of T lymphocyte subsets, including CD 3 +、CD 4 + and CD 8 +, and the survival time in model mice were observed. Results: Comparing with the control group, FZKBG could obviously increase both the percentage and absolute value of CD 3 +and CD 4 + lymphocytes and prolong the survival time of model mice, the prolongation rate being 29 6%-60 4%. Conclusion: FZKBG could markedly prolong the survival time of MRL mice, its mechanism might be through elevating the immune function and inhibiting the leukemic cells in model mice.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2001年第2期123-125,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局重点资助课题!(No .92 2 1 53)
