摘要
刺猬(hedgehog,Hh)信号通路是一条与成骨相关的信号通路。在胚胎发育期间,它调控祖细胞的生长和分化及各组织的形成。当肝脏受到损伤后,这条信号通路被激活。活化的Hh信号通路参与肝损伤修复反应的多个方面,包括肝祖细胞的增殖,肌成纤维细胞的转化与生成,肝脏多种细胞的凋亡,与肝损伤引起的炎症反应以及血管重塑过程等。该文将对近年来Hh信号通路参与肝损伤修复机制的研究及可能的药物作用靶点作一综述,旨在为抗肝纤维化的研究提供新的视角和治疗靶标。
Hedgehog pathway is an osteogenesis-related signaling pathway. During embryonic development , it regulates the growthand proliferation of progenitor cells and tissue formation. This pathway can be activated during liver injury. Activated Hedge- hog signaling pathway is involved in many aspects of liver wound-healing responses, including hepatic progenitor cell pro- liferation, myofibroblast transdifferentiation, apoptosis of various types of liver cells, inflammatory reactions, and vascular remod- eling. This article reviews the research progress in the role ofHedgehog signaling pathway in liver injury and the underlying mechanisms. The potential drug targets are also discussed. This review is to provide novel insights into antifibrotic research and therapeutic targets.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第4期460-464,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81270514
30873424)
教育部博士点基金项目(No 20103237110010)
江苏省自然科学基金资助项目(No BK2008456)
江苏省六大人才基金(No 2009-B-010)
江苏高校优势学科建设工程资助项目(No ysxk-2010)
南京中医药大学中药学一级学科开放课题资(No 2011ZYX4-008)
十一五科技支撑计划(No2008BAI51B02)
关键词
Hh信号通路
肝损伤
修复反应
肝纤维化
机制研究
治疗靶标
Hedgehog pathway
liver injury
wound-healing re- sponses
liver fibrosis
mechanistic research
therapeutic target
