摘要
应用核酸杂交技术检测54例广西地区子宫颈癌活检标本的HPVs基因组相关序列,结果阳性24例,阳性率为44.44%;HPV型别分布以HPV16型(13例,54.16%)和HPVR型(6例,2500%)为主.研究表明,广西地区相当部分宫颈癌的发生与HPV感染有关.
The HPV 16 DNA-related sequences and the histological features were ana-lysed in the biopsy specimens from 54 patients with carcinoma of the uterine cervix, givinq thefollowing results: (1) All of the 13 cases of HPV type-16 and 3 cases of HPV type-11/6were found to he squamous cell carcinoma; 4 of the 6 cases with HPV type-R were alsosquamous cell carcinoma. (2) The specific histological features of the cervical cancerous tissueswere different in different HPV types. (3) The HPV 16 DNA-homologous sequences were ana-lysed with the southern blot hybridization technics and pathomorphological examination.Their results agree with each other.
关键词
子宫颈肿瘤
乳头瘤病毒
核酸杂交
papillomavirus infections
cervix neoplasms
nucleic acid hybridization technics
pathomorphology
