摘要
采用手性衍生化试剂：（Ｓ）（－）Ｎ－三氟乙酰－１－脯胺酰氯（ＴＰＣ）和（Ｒ）（＋）－α－甲氧基－α－三氟甲基苯乙酸（ＭＴＰＡ）与安非他明类对映体反应生成非对映体衍生化产物，通过常规的ＧＣ／ＭＳ方法将其分离。本文较系统地考察了这两种手性试剂衍生化反应中溶剂、手性试剂用量、加热温度、反应时间等因素对安非他明类对映体衍生化结果的影响。实现了Ａｍ、ＭＡｍ、ＭＤＡ、ＭＤＭＡ、ＭＤＥＡ、ＭＢＤＢ等几种毒品对映体间的良好分离。
Most drugs of amphetamines contain chiral centers, which form different optical isomers, or enantiomers. Because different enantiomers have different pharmacological effect and have different machnism of metabolism. Besides, the ratio of the two eanatiomers could reflect the mute and method used in the synthesis of the drugs. So the separation and determination of these eanantiomers for seizured samples or for biological samples became very important in the sence of forensic science. The paper used two chiral reagents: N-trifluroacetylprolyl chloride (TPC) and (R)-( +)-alpha -methoxy-alpha-(trifluoromethyl)phenylacetic acid (MTPA) to reach the purpose. They reacted with amphetamine enantiomers to form diasteromeric pairs, which possess some differences in physical and chemical natures and could be separated by GC/MS. The paper examined in detail some fectors such as the solvents, chiral reagent amounts, reaction time, temperature, etc. on the effect of chiral derivatization. Some enantiomers of amphetamine (Am), N-methylamphetamine( MAm), 3, 4-methylenedioxyamphetamine (MDA), 3, 4-methylenedioxy-N-methylamphetamine (MDMA), 3, 4-methylenedioxy-N-ethylamphetamine (MDEA) and N-methyl-1-(3, 4-methylenedioxy)-2butanamine (MBDB) were well separated each other.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2001年第2期182-185,共4页
Chinese Journal of Analytical Chemistry
关键词
毒品
手性试剂
安非他明
气相色谱-质谱
手性对映体
分析
TPC
MTPA
illicit drug
enantiomer
amphetamines
chiral derivatization
chiral separation
gas chromatography-mass spectrometry
N-trifluroacetylprolyl chloride
(R)-(+)-alpha-methoxy-alpha-(trifluromethyl) phenylacetic acid
