摘要
目的 观察急性冠脉综合征（ACS）长期应用二联抗血小板治疗中的心血管事件与出血风险.方法 自2011年9月1日～ 2012年9月1日连续募集在解放军总医院心血管研究所住院并明确诊断为ACS的患者168例,给予常规二联抗血小板（氯吡格雷＋阿斯匹林）治疗,定期随访至1年,观察患者心血管事件与出血并发症.结果 随访153例,其中老年组87例,年轻组66例,均无严重出血事件发生.老年组出现轻微出血5例,心血管事件14例;年轻组轻微出血9例,心血管事件12例.ACS患者二联抗血小板治疗1年,老年人与年轻人两组之间比较,心血管事件与出血并发症的发生率相似（P＞0.05）.结论 老年ACS患者长期二联抗血小板治疗并未增加出血风险,用药相对安全.
Objective To observe the cardiovascular events in patients with acute coronary syndrome （ACS）who received long term dual antiplatelet therapy and to evaluate the risk of bleeding. Methods 168 patients with ACS who were hospitalized between September 2011 and September 2012 in the institute of geriatric cardiology of PLA General Hospital were selected and received the conventional dual antiplatelet therapy（clopidogrel ＋ aspirin）. The regular follow-up was made during the late one year. The patients＂ cardiovascular events and complications of bleeding were observed. Results 153 cases were followed up, including 87 cases in senile group and 66 ones in young group. There was no case of severe bleeding events. In the senile group, there were 5 cases of mild bleeding and 14 ones of cardiovascular events. In the young group,there were 9 cases of mild bleeding and 12 ones of cardiovascular events. The ACS patients had received the dual antiplatelet therapy for one year. The incidences of cardiovascular events and bleeding complications between the senile and the young group were the similar （P 〉 0.05）. Conclusions Long term dual antiplatelet therapy on senile ACS patients does not increase the risk of bleeding. The medication is relatively safe.
出处
《西南国防医药》
CAS
2014年第4期352-355,共4页
Medical Journal of National Defending Forces in Southwest China
基金
国家自然科学基金面上项目(81100215
30971259)
解放军总医院临床扶持基金(2012FC-TSYS-3042)
关键词
急性冠脉综合征
二联
抗血小板
出血
心血管事件
acute coronary syndrome
bigeminy
antiplatelet
bleeding
cardiovascular event
