摘要
针对电学比拟法设计微流体浓度分配网络芯片所存在的芯片体积大与兼容性不好等问题,提出了一种基于拓扑优化的设计方法。针对多输入端口多输出端口的微流控芯片建立了流体网络自适应调整管道体积的设计优化模型。数值算例表明该模型适用于任意指定的流量分配设计要求。同时,设计方法可以直接扩展到三维情况,以经典多层浓度梯度网络的设计为应用算例,验证了改进设计方法的实用性及集成性,对于微流控网络的大规模集成设计的发展将起到很大的促进作用。
An improved topology optimization design method is proposed to overcome the disadvantages of the commonly used microfluidic network chip design method, such as large chip volume and limited compatibility. Math ematical optimization models, which focus on multiple inlets and multiple outlets with specified flow rates, are estab lished with adaptive adjustment of the chip volume. Numerical examples demonstrate that the proposed method can accurately design microfluidic chips with a variety of distributions of flow rates at outlets. At the same time, the pro posed method can be extended to three dimensional cases directly without sacrificial accuracy. Multiple layers design of the micro network gradient chip is re designed based on the proposed method to show the practicability and in tegration. Therefore, the proposed method has potential applications as an attractive choice to design large scale mi crofluidie networks.
出处
《计算机仿真》
CSCD
北大核心
2014年第4期223-226,237,共5页
Computer Simulation
关键词
拓扑优化
微流体
浓度梯度
流量分配
多层优化
Topology optimization
Microfluidic
Gradient chip
Specified outlet flow rates
Multiple design
