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成纤维细胞生长因子21:从生理作用到临床研究 被引量：4

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摘要 成纤维细胞生长因子21(FGF21)是FGF家族中的新成员。目前研究显示,FGF21是一个新的糖脂代谢调节因子,有望成为治疗糖尿病等代谢性疾病的新型药物。FGF21能改善胰岛功能,促进葡萄糖的吸收,减少脂肪的堆积。FGF21是FGFs家族中没有促有丝分裂的基因,并且有明显的组织特异性,从而大大降低了临床用药的风险。随着代谢性疾病人群的增多,FGF已成为国际上的研究热点。本文描述FGF21的功能及研究进展。
作者 付坤 柳景华
机构地区 首都医科大学附属北京安贞医院 北京市心肺血管疾病研究所心内科
出处 《中国循环杂志》 CSCD 北大核心 2014年第4期309-311,共3页 Chinese Circulation Journal
基金 国家自然科学基金(81070227) 北京市教育委员会科技计划面上项目(km201110025019)
关键词 FGF21 糖脂代谢 游离脂肪酸 胰岛素抵抗
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献29

  • 1ltoh N, Ornitz DM. Fibroblast growth faclors: from molecular evolution to roles in development, metabolism and disease. J Biochem, 2011, 149: 121-130.
  • 2柳景华,吕昀,张立克,郝刚,曾翔俊,赵东晖,方冬平,何东方,张英川.成纤维细胞生长因子21基因在心脏中表达的研究[J].心肺血管病杂志,2009,28(6):415-418. 被引量：20
  • 3Micamwic R, Raches DW, Dunbar JD, et al. Different roles of N- and C- termini in the functional activity of FGF21. J Cell Physiol, 2009, 219: 227-234.
  • 4Smith R, Duguay A, Weiszmann J, et al. A novel approach to improve the function of FGF21. Bin Drugs, 2013, 27: 159-166.
  • 5Li Y, Wong K, Walsh K, et al. Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem, 2013, 288: 10490-10504.
  • 6Xu J, Lloyd DJ, Hale C, et al. Fihrohlast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes, 2009, 58: 250-259.
  • 7Dutchak PA, Katafuchi T, Bonkout AL, et al. Fibroblast growth factor-2l regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones. Cell, 2012, 148: 556-567.
  • 8Uebanso T, Taketani Y, Yamamnto H, et al. Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? PLoS One, 2011, 6: e22976.
  • 9Li H, Gao Z, Zhang J, et al. Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes, 2012, 61: 797-806.
  • 10De Sousa-Coelho AL, Marrero PF, Haro D. Activating transcription tactor 4-dependent induction of FGF2I during amino acid deprivation. Binchem J, 2012, 443: 165-171.

二级参考文献14

  • 1刘静,赵冬,王薇,刘军,孙佳艺,吴兆苏.北京自然人群代谢综合征发病率及影响因素的研究[J].心肺血管病杂志,2007,26(2):65-68. 被引量：14
  • 2中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量：5227
  • 3Nishimura T, Nakatake Y, Konishi M,et al. Identification of a novel FGF, FGF21, preferentially expressed in the liver. Biochim Biophys Aeta,2000,1492:203-206.
  • 4Izumiya Y, Bina HA, Ouchi N, et al. FGF21 is an Akt- regulated myokine. FEBS Letters, 2008,582:3805-3810.
  • 5Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology, 2008, 149: 6018-6027.
  • 6Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes, 2009,58:250-259.
  • 7Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology, 2007,148 : 774-781.
  • 8Lundasen T, Hunt MC, Nilsson LM, et al. PPAR alpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun, 2007,360:437-440.
  • 9Galman C, Lundason T, Kharitonenkov A, et al. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPAR alpha activation in man. Cell metab,2008, 8 : 169-174.
  • 10Nishida M, Carley WW, Gerritsen ME, et al. Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol, 1993,264: 639-652.

共引文献67

同被引文献34

  • 1王会岩,张耀方,万晓珊,解佳森,肖业臣,李校堃.人成纤维细胞生长因子-21分泌型表达及鉴定[J].吉林农业大学学报,2009,31(3):255-257. 被引量：9
  • 2姚成灿,郑青,许华,赵文,吴晓萍,苏志坚,黄亚东,李校堃.重组人酸性成纤维细胞生长因子的稳定性研究[J].中国现代应用药学,2006,23(5):358-360. 被引量：3
  • 3Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease [J]. J Biochem, 2011, 149 (2) : 121-130.
  • 4Smith R, Duguay A, Weiszmann J, et al. A novel approach to improve the function of FGF21[J]. Biol Drugs, 2013,27 (2): 159-166.
  • 5Zhu WH, Wang CW, Wang HY, et al. Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo [J]. Can J Physiol Pharmaeol, 2014, 92 (11): 927- 935.
  • 6Fisher FM, Chui PC, Antonellis PJ, et al. Obesity is a fihrohlast growth factor 21 (FGF21) -resistant state [J]. Diabetes, 2010, 59 (11): 2781-2789.
  • 7Zhang J, Li Y. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome [J]. Drug Discov Today, 2014, 19 (5): 579-589.
  • 8Wang HY, Xiao YC, Li XK, et al. High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli [J ]. BMC Biotechnol, 2010, 10 (1): 14-23.
  • 9Brian MB, Bernhardt LT. Rational design of solution additives for the prevention of protein aggregation [J ]. Biophys J, 2004, 87 (3): 1631-1639.
  • 10Song LT, Zhu YL, Huang ZF, et al. A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog [J]. Biomaterials, 2014, 35 (3) : 5206-5215.

引证文献4

二级引证文献11

中国循环杂志
2014年 第4期

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