摘要
目的探讨小儿川崎病（KD）的诊断及治疗方法。方法对52例KD患儿的临床表现、辅助检查及治疗方法和治疗效果进行回顾性分析。综合性治疗基础上，治疗组（26例）应用丙种球蛋白静脉滴注（IVIG）连续治疗2次，对照组（26例）应用IVIG治疗1次。IVIG治疗无效的患儿应用糖皮质激素治疗。结果小儿KD的诊断主要靠临床表现；治疗组总有效率为92．3％，对照组为69．2％，两组比较差异有统计学意义（P〈0．05）；治疗组冠状动脉病变率为0，对照组为19．2％，两组比较差异有统计学意义（P〈0．05）；IVIG治疗无效的患儿加用糖皮质激素可缩短发热时间。结论联合应用IVIG和阿司匹林口服是小儿KD的首选治疗方案；IVIG连续应用2次疗效显著，可明显降低冠状动脉病变率；IVIG治疗无效的患儿加用糖皮质激素有一定的疗效。
Objective To investigate the diagnosis and treatment of children with Kawasaki dis- ease（KD）. Methods The clinical manifestation, auxiliary examination, treatment methods and treat- ment effects of 52 children with KD were retrospectively analyzed. On the basis of comprehensive treat- ment, the patients in treatment group （26 cases） were treated with intravenous gamma globulin （IVIG）for 2 consecutive times, and the patients in control group （26 cases） were given IVIG for 1 time. The invalid children of IVIG were treated with glucocorticoid. Results The diagnosis of children with KD depended on clinical manifestations ;The total effective rate in the treatment group was 92. 3%, and that in the control group was 69. 2%, there was significant difference（P 〈0. 05） ; Rate of coronary artery lesions in the treat- ment group was 0, and that in the control group was 19. 2%, there was significant difference （ P 〈 0. 05 ） ; The invalid children of IVIG with glucocorticoid could shorten the heating time. Conclusions Combined use of IVIG and oral aspirin is the preferred treatment method for children with KD;the curative effect of IVIG for 2 consecutive times is distinct, which can obviously reduce the rate of coronary artery lesions; the invalid children of IVIG with glucocorticoid has certain curative effect.
出处
《中国实用医刊》
2014年第9期54-56,共3页
Chinese Journal of Practical Medicine
关键词
小儿
川崎病
临床分析
Infant
Kawasaki disease
Clinical analysis
