摘要
目的探讨前列地尔注射液联合罂粟碱治疗缺血性结肠炎的疗效。方法选取符合入选标准的48例缺血性结肠炎患者，随机分为治疗组28例和对照组20例。对照组给予罂粟碱、抗生素及常规对症支持治疗。治疗组在前述治疗基础上加用前列地尔。疗程结束后观察两组治疗前后症状、大便潜血、血流变学、肠镜等的变化情况。结果治疗组腹痛、大便潜血恢复时间以及住院天数均比对照组缩短，治疗1周后治疗组的血液黏稠度、血浆纤维蛋白原均低于对照组，差异均有统计学意义（P〈0．05）。治疗组总有效率、显效率明显优于对照组（P〈0．05）。结论前列地尔注射液联合罂粟碱可降低缺血性结肠炎患者的高凝状态，促使症状恢复快，缩短病程。
Objective To investigate the therapeutic effect of alprostadil combined with papaver- ine on patients with ischemic colitis. Methods Forty-eight patients with ischernic colitis were selected and randomly divided into the treatment group （n = 28 ） and the control group （n = 20）. The control group were treated with papaverine, antibiotics and conventional symptomatic treatment and the treatment group were given alprostadil therapy on the basis of the treatment for the control blood rheology and colonoscopy before and group. The changes of abdominal pain, fecal occult blood, after the treatment were observed. Results Compared with the control group, the length of days with abdominal pain, fecal occult blood positive and stay were short- ened. After a week of the treatment, the results of plasma viscosity and fibrinogen level in treatment group were significantly lower than those in the control group （ P 〈 0. 05 ）, and the total effective rate and efficiency rate of treatment group was better than that of control group （ P 〈 0.05 ）. Conclusions A1- prostadil combined with papaverine can reduce hypercoagulable state, and contribute to the recovery of symptoms and shorten course for patients with ischemic colitis.
出处
《中国实用医刊》
2014年第9期51-53,共3页
Chinese Journal of Practical Medicine
