摘要
简要介绍了在不同实验体系中利用共刺激作用原理来增强T淋巴细胞抗肿瘤免疫反应的研究进展,并进一步讨论了如何将其应用于肿瘤的免疫治疗。
In the course of T cell activation by tumor cells, signal induced by interaction between T cell receptor and MHC-antigen peptide complex is essential but not enough. At least one additional signal, signal-2 or accessory signal, is needed, which is induced by the ligation of co-stimulatory molecules expressed on APC (antigen-presenting cell) and their conterreceptors on T cells. Tumor cell may escape the immune surveillance by lacking of co-stimulatory molecules, resulting in low immunogecity. By now, quite a few co-stimulatory molecules have been found and some of them have been extensively investigated. Here we will give a biref review on the present progress of the co-stimulatory molecules and their application in cancer medicine.
出处
《中国科学基金》
CSCD
2000年第6期328-331,共4页
Bulletin of National Natural Science Foundation of China
