摘要
目的:探讨低分子肝素钙联合奥拉西坦治疗老年人血管性认知功能障碍(vascular cognitive impairment,VCI)的疗效。方法:将60例老年VCI患者随机分为对照组,奥拉西坦组,低分子肝素钙联合奥拉西坦组(联合组),每组20例。在常规治疗的基础上,对照组给予安慰剂治疗;奥拉西坦组口服奥拉西坦,800 mg/次,3次/d;联合组口服奥拉西坦800 mg/次,3次/d,皮下注射低分子肝素钙,5000 U,1次/d;疗程为2个月。采用简易智力状态检查量表(mini-mental state examination,MMSE)和日常生活能力量表(activity of daily living,ADL)评价疗效。结果:2个月后联合组MMSE和ADL评分显著提高(P<0.01)。结论:低分子肝素钙联合奥拉西坦可以显著改善老年人VCI。
Objective： To explore the effect of low molecular-weight heparin calcium combined with oxiracetam on vascular cog- nitive impairment（VCI） in elderly people. Methods：Sixty elderly VCI patients were randomly divided into controll group, ox- iracetam group and combined group, with 20 cases in each group. The patients in the eontroll group were given conventional therapy and placebo. Oxiracetam （800 mg each time, 3 t/d） was added in oxiracetam group on the basis of conventional thera- py. Oxiracetam （800 mg each time, 3 t/d） and low-molecular weight heparin calcium（5000 U, 1 t/d） were added in combined group on the basis of conventional therapy. The treatment lasted for 2 months. Using mini-mental state examination （MMSE） and activity of daily living scale （ADL） to evaluate the effect. Results： After 2 months, MMSE and ADL scores of the com- bined group increased （P〈0.01）. Conclusions： The combination of oxiracetam with low-molecular-weight heparin calcium can significantly improve the cognitive function of elderly VCI patients.
出处
《中国临床医学》
2014年第1期29-30,共2页
Chinese Journal of Clinical Medicine
关键词
老年人
血管性认知和功能障碍
奥拉西坦
低分子肝素钙
Elderly people
Vascular cognitive impairment
Oxiracetam
Low-molecular-weight heparin calcium
