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脂滴在丙肝病毒生命周期中的作用 被引量：2

Roles of Lipid Droplets in Hepatitis C Virus Life Cycle
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摘要 脂滴是细胞内中性脂的主要储存细胞器。最近许多研究都发现脂滴与丙型肝炎病毒(Hepatitis C virus,HCV)有着密切的关系。脂滴对HCV的生命周期发挥着重要作用,影响HCV的感染、复制、组装和分泌一系列生命过程。本文就脂滴在病毒生命周期中的作用的最新进展进行综述。 Abstract：Lipid droplets are the main storage organelles for intracellular neutral lipids. Many recent studies have found that lipid droplets are closely related to hepatitis C virus （HCV）. Lipid droplets play important roles in the multiple processes of HCV life cycle, such as infection, replication, assembly, and secretion. In this review, we summarize the recent research progress in the roles of lipid droplets in Hcv life cycle.
作者 杨小洁 张磊亮
机构地区 中国医学科学院北京协和医学院病原生物学研究所卫生部病原系统生物学重点实验室
出处 《病毒学报》 CAS CSCD 北大核心 2014年第1期91-97,共7页 Chinese Journal of Virology
基金 中国国家自然科学基金面上项目(81271832)
关键词 脂滴 丙型肝炎病毒 core蛋白 NS5A蛋白 Key words. Lipid droplets Hepatitis C virus Core NS5A
分类号 R373.9 [医药卫生—病原生物学]
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参考文献48

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同被引文献30

  • 1刘敏,李献平.利肝降脂汤治疗慢性病毒性肝炎合并脂代谢紊乱的临床研究[J].北京中医药大学学报,2004,27(6):83-84. 被引量：2
  • 2杨智才,杨玲霏,钟益均.脂肪肝与丙型肝炎病毒感染的相关性[J].广东医学,2007,28(11):1813-1814. 被引量：1
  • 3LONARDO A, LORIA P, ADINOLTL LE, et al. Hepatitis C virus -infected patients are 'spared' from the metabolic syn- drome but not from insulin resistance. A comparative study of nonalcoholic fatty liver disease and hepatitis C virus - related steatosis [ J ]. Can J Gastroenterol,2009 ,23 (4) : 273 - 278.
  • 4MIYANARI Y ,ATSUZAWA K , USUDA N, et al. The lip- id droplet is an important organelle for hepatitis C virus pro- duction [ J ]. Nat Cell Biol,2007,9 ( 9 ) : 1089 - 1097.
  • 5SHAVINSKAYA A,BOULANT S,PENIN F, et al. The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly [ J ]. J Biol Chem, 2007,282(6) :37158 - 37169.
  • 6MIRANDOLA S,REALDON S,LQBAL J,et al. Livermiero- somal triglyceride transfer protein is involved in hepatitis C liver steatosis [ J ]. Gastroenterology, 2006, 132 ( 4 ) : 1661 - 1669.
  • 7NEVO-YASSAF I ,YAFFE Y ,ASHER M ,et al . Role for TBC1D20 and Rabl in hepatitis C virus replication via inter- action with lipid droplet-bound nonstructural protein 5A [ J]. Virol,2012,86(12) :6491 - 6502.
  • 8LEANDRO G,MANGIA A, HUI J, et al. Relationship be- tween steatosis,inflammation,and fibrosis in chronic hepati- tis C : a meta analysis of individual patient data [ J ]. Gastro- enterology, 2006,130 ( 6 ) : 1636 - 1642.
  • 9AL-QAHTANI A , SANAI FM , AL-HAMOUDI H,et al. Prevalence and impact of hepatic steatosis on the response to antiviral therapy in Saudi patients with genotypes 1 and 4 chronic hepatitis C [J]. Dig Dis Sci ,2011,56 (4): 1222 - 1228.
  • 10HSU CS, LIU CH, LIU C J, et al . Association of lipid pro- files with hepatitis C viral load in chronic hepatitis C pa- tients with genotype 1 or 2 infection [ J] . Am J Gastroen- tero1,2009,104( 3 ) :598 - 604.

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病毒学报
2014年 第1期

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