摘要
Magnetocardiography(MCG) has been investigated as a tool for noninvasive detection of coronary artery disease(CAD). In this study, the area ratio of positive and negative magnetic induction extracted from an extrema circle in the magnetocardiogram was analyzed at specific time points in the cardiac cycle: P maximum, R peak, J point, T onset, T peak and T end. The area of the positive proportion of the magnetic field relative to the total area within a circle encompassing the field extrema was determined and proposed for fast-speed CAD diagnosis. MCG was performed with a 61-channel biomagnetometer in a shielded environment in 38 healthy subjects and 15 CAD patients. A notable difference in area ratio was found between healthy and CAD subjects at the peak time of T wave: 0.416 ± 0.090 versus0.465 ± 0.065(p = 0.013). Using a cutoff value of 0.4506resulted in a sensitivity and specificity of 86.7 % and 73.8 %,respectively. This approach may enable a fast-speed CAD diagnosis in a clinical setting.
Magnetocardiography （MCG） has been investi- gated as a tool for noninvasive detection of coronary artery disease （CAD）. In this study, the area ratio of positive and negative magnetic induction extracted from an extrema cir- cle in the magnetocardiogram was analyzed at specific time points in the cardiac cycle： P maximum, R peak, J point, T onset, T peak and T end. The area of the positive proportion of the magnetic held relative to the total area within a circle encompassing the field extrema was determined and pro- posed for fast-speed CAD diagnosis. MCG was performed with a 61-channel biomagnetometer in a shielded environ- ment in 38 healthy subjects and 15 CAD patients. A notable difference in area ratio was found between healthy and CAD subjects at the peak time of T wave： 0.416 ± 0.090 versus 0.465 ±0.065 （p = 0.013）. Using a cutoff value of 0.4506 resulted in a sensitivity and specificity of 86.7 % and 73.8 %, respectively. This approach may enable a fast-speed CAD diagnosis in a clinical setting.
基金
supported in part by the National Natural Science Foundation of China(60771030)
the National High-Technology Research and Development Program of China(2008AA02Z308)
the Shanghai Science and Technology Development Foundation(08JC1421800)
the Open Project of State Key Laboratory of Function Materials for Information(Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences)
the key Laboratory of Medical Imaging Computing andComputer Assisted Intervention of Shanghai(13DZ2272200-2)
Shanghai Leading Academic Discipline Project(B004)
