摘要
目的探讨血清促炎细胞因子白细胞介素-6(IL-6)及降钙素原(PCT)水平在早期评估急性胰腺炎(AP)患者严重程度及预后的价值。方法以28例重症急性胰腺炎(SAP)和36例轻症急性胰腺炎(MAP)患者为研究对象,另以47名健康体检者作为对照组。采用酶联免疫吸附试验(ELISA)检测血清IL-6及PCT水平,分析二者与患者Ranson评分、APACHEⅡ评分、Bahhazar CT评分、血清生化指标及预后的关系。结果 SAP组、MAP组、健康对照组血清IL-6水平分别为(531.37±168.67)pg/ml、(261.32±178.55)pg/ml、(15.31±3.15)pg/ml,三组间差异均有统计学意义(P均<0.01)。SAP组、MAP组、健康对照组血清PCT水平分别为(4.22±2.84)ng/ml、(0.45±0.33)ng/ml、(0.12±0.11)ng/ml,三组间PCT值差异均有统计学意义(P均<0.05)。血清IL-6和PCT水平与Ranson评分、APACHEⅡ评分、Balthazar CT评分均呈正相关。结论血清IL-6和PCT水平与急性胰腺炎病情的严重程度和并发症显著相关。
Objective To investigate the value of using proinflammatory cytokine interleukin - 6 （ IL - 6） and procalcito- nin（PCT） to assess the severity and prognosis of acute pancreatitis （AP）. Methods Chose 28 cases of severe acute pancreatitis （SAP） and 36 eases of mild acute pancreatitis （MAP） for the study group, the other 47 healthy subjects for the control group. We utilized enzyme -linked immunosorbent assay（ELISA） to detect the serum IL -6 and PCT level, and analyzed the relationship between the two levels and the patients Ranson score, APACHE ]I score, Bahhazar CT score, serum biochemical markers and prognosis respectively. Results In SAP group, MAP group and healthy control group respectively,the serum IL -6 levels were（531.37 ± 168.67） pg/ml, （261.32 ± 178.55） pg/ml, （ 15.31 ±3. 15） pg/ml, the differences among the three groups were statistically significant （P 〈 0. 01 ）, and the serum PCT levels were （4. 22±2. 84） ng/ml, （0. 45 ± 0. 33 ） ng/m], （0. 12 ± 0. 11 ） ng/ml, the differences were also statistically significant （P 〈 0. 05）. Serum levels of IL - 6 and PCT were positively correlated with Ranson score,APACHE 11 score, Balthazar CT score. Conclusion The serum IL -6 and PCT levels were significantly associated with the severity and complica- tions of acute pancreatitis.
出处
《医药论坛杂志》
2014年第2期21-22,25,共3页
Journal of Medical Forum
