摘要
目的探讨2型糖尿病(T2DM)合并颈动脉粥样硬化(AS)患者血清网膜素水平的变化及临床意义。方法根据有无颈动脉斑块形成将64例2型糖尿病患者分为AS-T2DM组(n=34)和2型糖尿病无AS(T2DM-non AS)(n=30)组。用酶联免疫吸附(ELISA)法测定空腹血清网膜素水平,记录病程、年龄、体质量指数(BMI),测定血糖(FBG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(CHO)等生化指标,颈动脉斑块检测采用超声彩色多普勒检查。结果 AS-T2DM组血清网膜素水平(4.34±1.55)ng/L低于T2DM-non AS组(10.86±2.66)ng/L(P<0.05)。网膜素水平与BMI成明显负相关,与HDL-C呈正相关(r=10.270,P<0.05),与年龄、HbA1c、空腹血糖、餐后血糖、TG、LDL-C、CHO无明显相关性(P>0.05)。结论提示网膜素的升高可能在T2DM合并AS发生、发展中起一定保护作用。
Objective To investigate the clinical significance and changes of omentin concentration in type 2 diabetes patients with carotid atherosclerosis. Methods Sixty-four patients with type 2 diabetes were randomly divided into atherosclerosis（AS-T2DM） group（ n =34） and non atherosclerosis （T2DM non AS）group（ n = 30） according to the presence or absence of carotid artery plaque. The message was recorded including age, body mass index（BMI）, fasting blood glucose（FBG）, postprandial blood glucose（PBG）, hemoglobin A1 c（ HbA1 c）, triglyceride（TG）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（ HDL-C）, total cholesterol（CHO） and so on. The fasting plasma omentin was measured by enzyme-linked immunosorbent assay（ELISA）. Carotid artery plaque was measured by color Doppler ultrasound. Results The fasting plasma omentin in AS group （4.34 ± 1.55） pg/L was lower than in non AS group（10.86±2.66） pg/L（ P 〈0.05）. The level of serum omentin showed negative correlation with BMI, but it had positive correlation with HDL-C（ r = 10. 270, P 〈0. 05）, and no correlation with age, HbAI c, FBG,PBG,TG,LDL-C,CHO. Conclusion Elevating serum omentin may play the role of protection in atherosclerosis occurrence and progress.
出处
《临床荟萃》
CAS
2014年第4期403-405,共3页
Clinical Focus
关键词
糖尿病
2型
动脉粥样硬化
网膜素
diabetes mellitus, type 2
atherosclerosis
omentin
