摘要
目的:探讨血清胱抑素C(Cys C)水平的变化对慢性心力衰竭(CHF)患者临床心功能变化评价的临床意义。方法:选取CHF组80例,健康体检正常者(对照组)30名。心力衰竭程度按纽约心脏病协会心功能分级法,采用免疫比浊法测定各组血清Cys C水平,并采用超声心动图测定左心室射血分数及左心室舒张末内径评价患者左心室功能,同时记录住院期间及出院6个月内患者的病死率和因CHF再次发作住院率。结果:CHF组患者血清Cys C水平显著高于对照组(P<0.01),且随着心功能分级的增高,血清Cys C水平也逐渐升高(P<0.01)。患者血清Cys C水平与左心室舒张末内径呈正相关关系(P<0.05),与左心室射血分数呈负相关关系(P<0.05)。高、低血清Cys C组中患者住院期间病死率差异无统计学意义(P>0.05),高血清Cys C组出院6个月病死率及因心力衰竭再住院率均升高(P<0.05)。结论:Cys C对于评价CHF患者临床心功能变化及评估预后具有一定意义。
Objective：To observe the change of serum Cystatin C （Cys C） level in patients with chronic heart failure（CHF）, and investigate the significance between Cys C level and cardiac function. Methods：The subjects were divided into CHF group（n = 80） and normal control group （n = 30）. Severity of CHF was according to New York Heat Association （NYHA） heart functional classes. Serum Cyst C level was measured by ELISA assay. The left ventricular ejection fraction and left ventricular end diastolic diameter were detected by ultrasonic cardiogram. The mortality and re-hospitalization for chronic heart failure were recorded during hospitalization and discharge from hospital within 6 months. Results： The level of serum Cys C in CHF group was higher than that in control group （ P 〈 0.01 ） , it was increased with the higher class of NYHA heart functional classification（ P 〈 0.01 ）. Serum Cys C level had negatively correlated with left ventricular ejection fraction, but positively correlated with left ventricular end diastolic diameter（ P 〈 0.05 ）. There was no statistical difference of the mortality between higher CysC level group and lower Cys C level group （P 〉 O. 05 ）. During following-up for 6 months, the re-hospitalization for chronic heart failure and fatality were higher in patients with higher Cys C level than in those with lower Cys C level（ P 〈 0.05 ）. Conclusions＇.. Serum Cys C level is a potential biomarker for diagnosis of chronic heart failure, and it can reflect the recent prognosis of chronic heart failure.
出处
《蚌埠医学院学报》
CAS
2014年第3期324-325,328,共3页
Journal of Bengbu Medical College
关键词
心力衰竭
胱抑素C
预后
heart failure
Cystatin C
prognosis
