摘要
目的分析广东省2011-2012年疑似预防接种异常反应（AEFI）的发生特征，评价AEFI信息管理系统运转情况及预防接种安全性。方法通过全国AEFI信息管理系统收集2011年1月1日至2012年12月31日报告的AEFI个案数据．通过广东省疫苗月报告系统收集同期全省疫苗接种数据，采用描述性流行病学方法对AEFI发生特征进行流行病学分析。结果2011-2012年广东省共报告AEF1个案9753例（报告发生率为89．77／100万剂次），男、女性分别5945、3808例；以≤1岁、2～7岁人群为主，分别占65．75％（6413／9753）、32．29％（3149／9753）。一般反应6211例（63．68％，6211／9753），其平均报告发生率为57．17／100万剂次，以发热、红肿、硬结为主；异常反应2969例（30．44％，2969／9753），平均报告发生率为27．33／100万剂次，以过敏性皮疹（2399例）、卡介苗淋巴结炎（137例）和血管性水肿（125例）为主，共占89．63％（2661／2969），其中严重异常反应193例（1.98％，193／9753），平均报告发生率为1．79／100万剂次，以过敏性休克（57例）、血小板减少性紫癜（20例）和过敏性紫癜（16例）为主，共占48．19％（93／193）。87．41％（8525／9753）AEF1个案发生在接种后当天或第2天，治愈和好转占97．75％（9534／9753）。异常反应调查诊断结论92．49％（2746／2969）由疾控机构调查组作出，89．59％（2660／2969）由县级机构作出。结论广东省AEFI监测敏感度较高，AFEI常发生在小年龄组和接种后当天或第2天，预后良好。
Objective To analyze occurrence features of adverse events following immunization （AEFI） and evaluate the operating quality of AEFI information management system and the immunization safety in Guangdong Province during 2011 -2012. Methods AEFI data reported from January 1,2011 to December 31, 2012 were collected through the National AEFI Information Management System. Records of vaccination in the same period were sourced from the monthly vaccination reporting system of Guangdong Province. The descriptive method was used to analyze the AEFI occurrence features. Results A total of 9 753 AEFI cases were reported （reported incidence rate, 89. 77 per million doses）, of which 60. 96% （5 945/9 753）were males and 39. 04% （3 808/9 753）were females, 65.75% （6 413/9 753） were aged one year and under and 32. 29% （ 3 149/9 753 ） were aged 2 - 7 years. Of all the AEFIs, 63.68% （6 211/9 753 ） were general reactions （ mean reported incidence rate, 57.17 per million doses）, 30.44% （2 969/9 753 ） were abnormal reactions （ mean reported incidence rate, 27.33 per million doses）, and 1.98% （ 193/9 753 ） were serious abnormal reactions （mean reported incidence rate, 1.79 per million do- ses）. Symptoms of general reactions were mainly fever, redness and swelling, or indurations. Anaphylactic rash （2 399 cases）, angioedema （125 cases）, and lymphadenitis of Bacilli Calmette-Guerin vaccine （BCG） （137 cases） accounted for 89.63% （2 661/2 969） of all the abnormal reactions. Anaphylacticshock （57 cases）, thrombocytopenic purpura （20 cases）, and allergic purpura （16 cases） accounted for 48. 19% （93/193） of serious abnormal reactions. Of all the AEFIs, 87.41% （8 525/9 753 ） occurred within 1 day after vaccination, and 97.75% （9 534/9 753 ） were cured or improved. Of all the diagnostic conclusions of abnormal reactions, 92. 49% （2 746/2 969 ） were provided by investigation teams of institu- tions for disease control and prevention, 89. 59% were provided by institutions for disease control and pre- vention at county level. Conclusion The sensitivity of AEFI surveillance in Guangdong was high. AEFls often occurred among young group, within 1 day after vaccination, and with favourable prognosis.
出处
《华南预防医学》
2014年第2期137-143,共7页
South China Journal of Preventive Medicine
关键词
疑似预防接种异常反应
疫苗
接种
Adverse event following immunization
Vaccines
Vaccination
