摘要
目的：研究不同血清标志物及分子标志物在肺癌不同病理亚型、原发灶与转移淋巴结间表达的差异．方法：对48例住院接受开胸手术切除原发病灶及转移淋巴结的患者进行4种血清标志物和6种分子标记物检测．结果：ERCC-1的表达在原发肿瘤和转移部位间有显著差异（P=0．007）；CEA的血清水平在不同肿瘤亚型患者间存在显著差异（P=0．008）．结论：标志物检测对于患者预后的判断及治疗方案具有一定价值．
AIM： To investigate the different expressions of ser um markers and molecular markers in the primary tumor and the metastatic lymph nodes of lung cancer patients with four histologi cal subtypes. METHODS： There were 48 cases of lung cancer patients who underwent thoracic surgery for removal of primary and metastatic lesions had been enrolled for testing. RESULTS： Expression of ERCC-1 was significantly different in primary tumors and metastatic sites （ P = 0. 007） and the serum level of CEA was significantly different for patients with different cancer subtypes （P = 0. 008 ）. CONCLUSION： Tumor molecular markers have value to estimate prognosis and select treatments for patients.
出处
《转化医学电子杂志》
2014年第1期24-29,共6页
E-Journal of Translational Medicine
关键词
非小细胞肺癌
转移淋巴结
分子标志物
血清标志物
non-small cell lung cancer
metastatic lymph node
molecular markers
serum markers
