摘要
目的：观察FOLFOX6方案与FOLFIRI方案交替治疗晚期结肠癌的临床疗效。方法：98例晚期结肠癌患者进行FOLFOX6方案与FOLFIRI方案交替治疗,第1疗程按FOLFOX6方案给药；第2疗程按FOLFIRI方案给药；2个方案14天重复1次,2次为1疗程,每2疗程复查,评价疗效。化疗4-6疗程,出现进展停止使用。结果：总有效率为60.2%,对98例患者进行了随访。TTP为9.8个月,1年生存期达80例（81.6%）。毒副反应主要是恶心、呕吐,骨髓抑制,末梢神经炎、迟发性腹泻,乙酰胆碱综合征,脱发等。结论：晚期结肠癌应用FOLFOX6与FOLFIRI交替方案治疗,减少了患者发生耐药性的机会和毒副反应。
Objective：To observe clinical efficacy and untoward effect of alternation using of FOLFOX6 and FOLFIRI. Methods：Alternation using of FOLFOX6 and FOLFIRI in 98 patients with advance colon cancer. The first thermotherapy treatment was FOLFOX6;the second thermotherapy treatment was FOLFIRI;14-day cycle, two times was one course;alternated use of the two chemotherapies, clinical efficacy were assessed after each 2 chemotherapies by rechecking, the patients received 4-6 thermotherapy treatment when effective, stopped treatment when progression of disease.Results：Overall response rate was 60.2%,98 patients were followed, time to progression（TTP） was 9.8 months, 80 patients survived one year （81.6%） , Toxic actions and side effects were mainly nausea, vomiting, myelosuppression, nerve endings neuropathy, delayed diarrhea, acetylcholine syndrome, hair loss and ect. Conclusion：Alternation using of FOLFOX6 and FOLFIRI reduced the resistance in patients with advance colon cancer, reduced the accumulative peripheral neurotoxicity and adverse reaction.
出处
《中国医药导刊》
2014年第3期456-456,460,共2页
Chinese Journal of Medicinal Guide
关键词
结肠癌
化疗
疗效
毒副反应
Colon cancer
Chemotherapy
Curative Efficacy
Toxic And Side-Effect
