摘要
目的：探讨D-二聚体（DD）在老年患者下肢深静脉血栓形成（DVT）中的预测临界值,以期能为临床诊断老年下肢DVT提供参考。方法：将482例采用酶联免疫吸附法检测DD的老年住院患者临床资料进行回顾性分析,发生下肢DVT者73例为DVT组,其中年龄60-79岁者34例,≥80岁者39例,未发生下肢DVT者409例为非DVT组。结果：DVT组DD平均值为（2.67±0.61）mg/L,非DVT组为（1.71±0.35）mg/L,DVT组明显高于非DVT组（P〈0.05）；DVT组年龄60-69岁患者DD平均值为（1.98±0.52）mg/L,年龄≥80岁患者为（7.08±0.82）mg/L,年龄≥80岁患者DD值高于60-69岁患者（P〈0.05）；将DD临界值分为0.5mg/L、1.0mg/L、2.0mg/L、3.0mg/L 4个级别,DD临界值为0.5mg/L时两个年龄段患者诊断DVT敏感性无统计学差异存在（P〉0.05）,对60-69岁患者诊断特异性高于≥80岁患者（P〈0.05）,DD临界值为1.0mg/L、2.0mg/L、3.0mg/L时诊断敏感性及特异性≥80岁患者均高于60-69岁患者,1.0mg/L时两个年龄段的敏感性及特异性比较差异无统计学意义（P〉0.05）,2.0mg/L、3.0mg/L时两个年龄段的敏感性及特异性比较差异具有统计学意义（P〈0.05）。结论：60-69岁老年患者DD预测下肢DVT时临界值以0.5mg/L适宜,年龄≥80岁的老年患者则DD临界值调整为2.0mg/L更为合适。
Objective：To investigate the D-dimer （DD） in elderly patients with lower extremity deep vein thrombosis （DVT） of the prediction critical value,in order to provide reference for clinical diagnosis of senile lower limb DVT.Methods：482 patients with DD enzyme-linked immunosorbent method of elderly hospitalized patients with clinical data were retrospectively analyzed,73 cases of lower limb DVT occurred for DVT group,in which 34 cases aged 60-79,p 80,39,409 cases lower extremity DVT occurred not as a set of DVT.Results：DVT group average DD（2.67±0.61）mg/L,not DVT group is（1.71±0.35）mg/L,DVT is significantly higher than non DVT group （P〈0.05）;DVT group aged 60 to 69 patients with DD norm is（1.98±0.52）mg/L,were at the age of 80 patients（7.08±0.82）mg/L,were the 80-year-old patients with DD values higher than 60-69 years old patients （P〈0.05）;DD the critical value can be divided into 0.5 mg/L,1.0mg/L,2.0mg/L,3.0mg/L,DD critical value of 0.5mg/L two ages sensitivity diagnosis of DVT in patients with no statistical difference （P〉0.05）,specificity is higher than in patients with 60-69 years old or 80 years old patients （P〈0.05）,the DD critical value of 1.0 mg/L,2.0 mg/L,3.0mg/L when the diagnostic sensitivity and specificity of 80 or more patients were higher than patients with 60-69 years old,1.0 mg/L when the sensitivity and specificity of the two ages is no statistically significant difference （P〉0.05）,2.0mg/L,3.0mg/L in two age groups the sensitivity and specificity of comparative differences statistically significant （P〈0.05）.Conclusion：60-69 years old elderly patients with DD forecast lower extremity DVT threshold level to 0.5mg/L is appropriate,age of 80 years old or older patients is DD threshold adjustment of 2.0 mg/L.
出处
《中国医药导刊》
2014年第2期313-314,共2页
Chinese Journal of Medicinal Guide
关键词
D-二聚体
下肢深静脉血栓
老年
D-dimer
Lower extremity deep vein thrombosis
Old age
