摘要
目的:分析乌司他丁在急性期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者中的应用价值。方法:选择在我院就诊的急性COPD患者92例,根据随机数字表法随机分为观察组和对照组各46例。对照组患者给予常规治疗,观察组患者在常规治疗的基础上给予乌司他丁,两组患者的疗程均为7d。对比分析两组患者的治疗效果。结果:观察组患者治疗后的FVC(2.79±0.38)、FEV1(1.91±0.62)、FEV1/FVC(73.89±11.83)均优于对照组患者(2.39±0.76)、(1.82±0.58)、(62.79±9.23);观察组患者治疗后的二氧化碳分压(50.28±4.91)低于对照组患者(54.49±5.03);观察组患者治疗后的动脉血氧分压(82.03±9.03)、pH值(7.46±0.31)高于对照组患者(73.39±6.93)、(7.31±0.27);观察组患者治疗后的CRP(10.89±4.51)、TNF-a(58.63±19.21)低于对照组患者(14.62±4.23)、(68.93±20.02)。结论:乌司他丁可以降低急性期COPD患者的炎性反应,改善肺功能。
Objective：To analysis the effects of application on Ulinastatin in the acute phase of （chronic obstructive pulmonary disease,COPD） patients.Methods：92 patients with acute COPD who treatment in our hospital,be randomly divided into observation group and control group according to random digits table method,46 cases in each group.The control group were given routine treatment,the observation group patients were given Ulinastatin based on conventional treatment,two group patients were treated for 7d.The treatment effect of two group patients were compared.Results：The FVC in the observation group patients after treatment （2.79±0.38） FEV1,（1.91±0.62）,FEV1/FVC（73.89±11.83） was better than the control group （2.39±0.76）,（1.82±0.58）, （62.79±9.23）;The carbon dioxide pressure in the observation group patients after treatment （50.28±4.91） were lower than control group patients （54.49±5.03）;The arterial oxygen pressure （82.03±9.03）,pH value （7.46±0.31） in observation group patients after the treatment was higher than control group （73.39±6.93）,（7.31±0.27）;The CRP （10.89±4.51）,TNF-a （58.63±19.21） in observation group patients after treatment were lower than control group （14.62±4.23）,（68.93±20.02）.Conclusion：Ulinastatin can reduce the inflammatory response in acute stage of COPD patients,improve lung function.
出处
《中国医药导刊》
2014年第2期276-277,共2页
Chinese Journal of Medicinal Guide
关键词
乌司他丁
慢性阻塞性肺疾病
急性期
Ulinastatin
Chronic obstructive pulmonary disease
Acute stage
