摘要
对D(-)-双氢苯甘氨酸现行工业化路线进行分析指出存在的不足,并提出改进方案,通过调整反应体系各物料配比并改变目标产物纯化结晶方式达到大幅降低反应副产物4,5-二氢环己烯甘氨酸的目的。合成工艺改进后D(-)-双氢苯甘氨酸产率92%以上,4,5-二氢环己烯甘氨酸含量1.2%以下。
Indicating current manufacturing shortcomings for D- dihydrophenylglycine and propose im- provement program, by adjusting the ratio of raw materials and the reaction products were purified and crys- tallized way to change the target to achieve a substantial reduction reaction byproducts 4, 5 - dihydro-cyclo- hexene glycine purposes. Improved Synthesis of D （-）-2,5-Dihydrophen- ylglycine yield 92% or more and 4,5 - dihydro cyclohexene glycine 1.2% or less.
出处
《浙江化工》
CAS
2014年第3期14-16,共3页
Zhejiang Chemical Industry
