摘要
目的建立稳定的受体肝纤维化大鼠小体积肝移植模型。方法采用肝纤维化的SD大鼠,行56.3%比例的小体积肝移植12例,95.8%比例的全肝移植12例。结果成功构建了受体肝纤维化大鼠小体积肝移植模型;受体肝纤维化大鼠的全肝移植组术后24 h肝功能、7 d生存率明显优于小体积肝移植组(P<0.05)。结论成功建立了受体肝纤维化大鼠小体积肝移植模型,可作为相关研究的有效动物实验平台。
Objective To establish the small-size liver transplantation model for cirrhotic rats. Methods Of the 24 SD cirrhotic rats,12 underwent small-size liver transplantation （56.3%） and 12 underwent whole liver transplantation （95.8%）. Results The small-size liver transplantation model was successfully established for cirrhotic rats. The liver function 24 h after operation and the 7-day survival rate were significantly higher in whole liver transplantation group than in small-size liver transplantation group （P＆lt;0.05）. Conclusion The small-size liver transplantation model for cirrhotic rats can be used as an animal experiment platform for liver transplantation-related research.
出处
《解放军医学院学报》
CAS
2014年第3期270-272,共3页
Academic Journal of Chinese PLA Medical School
关键词
肝移植
肝纤维化
小体积供肝
动物模型
liver transplantation
liver fibrosis
small-size liver donor liver
animal model
