摘要
伴随人口老龄化,阿尔茨海默病逐渐成为引起老年人死亡的第四大病因。其致病因素和发病机制目前尚未清晰,发病机制以β淀粉样蛋白(Aβ)沉积、tau蛋白过度磷酸化和神经元变性死亡等学说为主。有关此病的研究多数着眼于治疗层面,尤其以药物的靶点为多,但因其病因的复杂多样性,随着研究的深入,药物的作用靶点也不断有新的发现,本文综述了抗阿尔茨海默病的非治疗药物及新靶点研究进展。
With the development of Chinese population aging,Alzheimer disease has become the fourth largest causes of death in the elderly.Pathogenic factors and pathogenesis of Alzheimer disease is not yet clear,Pathogenesis is based on theories of β-amyloid （Aβ） deposition,tau hyperphosphorylation and neuronal degeneration and death and others.Most studies on AD focus on the treatment of the disease,especially for drug targets.However,because of the complexity and diversity of the cause,with further research,drug targets are constantly new discoveries.In this paper,the progress of non-treatment drug and new targets for Alzheimer disease resistance are reviewed.
出处
《中国医药导报》
CAS
2014年第6期162-166,共5页
China Medical Herald
基金
国家自然基金资助项目(编号81273193)
