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阿尔茨海默病β-分泌酶1调控机制研究进展 被引量：3

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摘要 按照国际标准,我国已进入老龄化社会,到2020年我国60岁以上老年人口将达2.4亿,痴呆的患病率有逐渐增加的趋势,老年痴呆的预防和治疗已显得越来越重要.目前全球的老年痴呆患者人数超过3 600万,预计每20年患者人数将增加1倍,到2030年将超过6 600万,2050年将超过1.15亿[1].阿尔茨海默病（AD）是一种以进行性认知障碍和记忆力损害为主的中枢神经系统退行性疾病,是导致痴呆的最常见类型,主要病理特征为大脑萎缩、含有β-淀粉样蛋白（Aβ）的神经炎性老年斑和神经元胞质中银染的神经原纤维缠结[2].Aβ的沉积能够造成细胞骨架蛋白减少、影响细胞膜稳定性、诱导氧化应激等,通过多种途径诱导细胞凋亡[3-4],目前被公认为AD发病的中心环节.而β-分泌酶1介导淀粉样前体蛋白（APP）的第1次剪切,为Aβ形成的限速酶[1],随着AD患病率的增加,β-分泌酶1表达的调控机制已成为AD研究的热点.
作者 高冉 王德生
机构地区 哈尔滨医科大学附属第一医院神经科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2014年第3期192-195,共4页 Chinese Journal of Neurology
关键词 阿尔茨海默病 Β-分泌酶 中枢神经系统退行性疾病 调控 细胞骨架蛋白 神经原纤维缠结 β-淀粉样蛋白 淀粉样前体蛋白
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献32

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二级参考文献41

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共引文献4

同被引文献49

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  • 10段武钢,孙全新,罗建武.齐拉西酮对精神分裂症患者社会功能和生活质量影响的对照研究[J].实用医学杂志,2010,26(8):1426-1428. 被引量：21

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中华神经科杂志
2014年 第3期

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