摘要
目的参照恒压器检测结果，评价以快、慢速液体营养负荷试验（LNLT）评价近端胃功能的可行性。方法在2013年4月至8月间选取健康志愿者20名。使用恒压器检测胃敏感性，测定基础腹压、胃感知阈值、胃不适阈值和胃疼痛阈值。使用恒压器测定平均空腹胃容积并以此反映胃容受性，之后健康志愿者在5min内饮人200mL液体试餐，以餐后60min内测得的餐后胃容积中的最大值减平均空腹胃容积量，以该差值（即胃适应性舒张容积）评价近端胃适应性舒张功能。在LNLT中，健康志愿者分别饮人流速为100和15mL／min（即快速和慢速）的液体试餐，测定阈值饮人量、饱胀饮入量和最大饮人量。快、慢速LNLT的结果问，以及LNLT结果与恒压器所测胃敏感性和胃适应性舒张功能间的关系行Pearson相关分析。结果健康志愿者的基础腹压、胃感知阚值、胃不适阈值、胃疼痛阈值、空腹胃容积、餐后最大胃容积、适应性舒张容积分别为（6．8±1．2）mmHg（1mmHg=0．133kPa）、（2．7±1．9）mrnHg、（5．2±2．0）mmHg、（7．3±2．1）mmHg、（188．7±80．O）mL、（505．2±133．7）mL、（316．5±87．7）mL，其中餐后最大胃容积的出现时间为餐后（9．8±3．3）rain。在快速LNLT中，健康志愿者的阈值饮人量、饱胀饮入量、最大饮人量分别为（209±96）、（501±148）、（674±199）mL，在慢速I。NLT中则分别为（107±43）、（340±134）、（524土213）mL，且快速和慢速LNLT间具相关性（r=0．768、0．825、0．856，P均〈0．01）。快速和慢速最大饮人量的出现时间分别为餐后（8．6±1．2）和（34．9±6．4）min。慢速阈值饮入量与胃感知阈值有关（r=0．714，P〈0．01），慢速饱胀饮人量与胃感知闾值、胃不适阈值、胃疼痛阂值有关（r=0．599、0．650、0．622，P均〈O．01）。近端胃适应性舒张容积与慢速饱胀饮入量、快速饱胀饮入量、慢速最大饮入量、快速最大饮入量有关（r=0．543、0．636、0．527、0．493，P均〈O．05）。结论慢速LNLT的阈值饮人量和饱胀饮人量可能较适宜用于评价胃感觉功能，快速饱胀饮人量可能较适宜用于评价胃适应性舒张功能。
Objective To evaluate the possibility of slow and rapid liquid nutrient loading test （LNLT） in the proximal gastric function assessment according to the results of gastric barostat testing. Methods From April to August in 2013, 20 healthy volunteer were selected. The sensitivity of gastric, basic abdominal pressure, gastric sensing threshold, gastric discomfort and pain thresholds were examined by barostat. The average gastric volume after fasting was tested by barostat, which reflected gastric accommodation. And then 200 mL liquild meal was taken in five minutes by the volunteers. The difference value between the maximum gastric volume in 60 minutes after taking the meal minus the average gastric volume after fasting was used to evaluate the proximal gastric adapted diastolic function. In LNLT, volunteers drank 100 mL/min and 15 mL/min （rapid and slow） liquid meal. The threshold value of drinking volume, satiety drinking volume and maximum drinking volume were determined. Pearsoncorrelation analyses were performed in the results of fast and slow LNLT, correlation between LNLT and sensitivity of gastric, gastric adapted diastolic function tested by barostat. Results The basic abdominal pressure, gastric sensing threshold, gastric discomfort and pain thresholds, gastric volume after fasting, maximum gastric volume and adapted diastolic volume was （6.8±1.2） mmHg （1 mmHg=0. 133 kPa）, （2.7±1.9） mmHg, （5.2±2.0） mmHg, （7.3±2.1） mmHg, （188.7±80.0） mL, （505.2±133.7） mL and （316.5±87.7） mL, respectively. The maximum gastric volume after the meal was at （9.8±3.3） min after meal. In rapid LNLT, the threshold value of drinking volume, satiety drinking volume and maximum drinking volume of volunteers was （209±96）, （501±148） and （674±199） mL, respectively, and that in slow LNLT was （107± 43）, （340 ± 134） and （524 ± 213） mL, respectively, there was correlation between rapid and slow LNLT （r = 0. 768, 0. 825 and 0. 856, all P〈 0.01）. The maximum drinking volume of rapid and slow LNLT was at （8.6±1.2） and （34.9±6.4） minutes after meal. Threshold value of drinking volume in the slow drinking test was positively correlated with the gastric sensing threshold （r=0. 714, P〈0.01）. Satiety drinking volume in the slow drinking test was correlated with gastric sensing threshold, gastric discomfort and pain thresholds （r=0. 599, 0. 650 and 0. 622, all P〈0.01）. The proximal gastric adapted diastolic volume was related with slow satiety drinking volume, rapid satiety drinking volume, slow maximum drinking volume and rapid drinking volume （r= 0. 543, 0. 636, 0. 527 and 0. 493 ,all P〈0.05）. Conclusions Threshold value of drinking volume and satiety drinking volume in the slow LNLT is more suitable for evaluating the sensitivity of stomach. Satiety drinking volume in the rapid LNLT is more suitable for the evaluating of gastric adapted diastolic function.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2014年第3期152-155,共4页
Chinese Journal of Digestion
基金
国家自然科学基金（81070299）
关键词
电子恒压器
液体负荷试验
近端胃
感觉阈
适应
生理学
Electronic barostat Liquid load tests Proximal stomach Sensory thresholds Adaptation, physiological
