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乳腺癌干细胞的生物学特性与治疗前景 被引量：4

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摘要 乳腺癌干细胞具有高致瘤性、转移性、耐药性等特点,其在乳腺癌的发生、发展、复发及转移过程中发挥重要作用。迄今为止,多数研究已阐述了乳腺癌干细胞的表型特征,并在此基础上建立分离和鉴定的方法,靶向乳腺癌干细胞的治疗也取得一定进展。该文现对上述方面作一综述。
作者 胡杨丽 杨举伦
机构地区 昆明医科大学成都军区昆明总医院临床学院 成都军区昆明总医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2014年第3期298-301,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 乳腺肿瘤 干细胞 表型 分离 肿瘤治疗 文献综述
分类号 R737.9 [医药卫生—肿瘤]
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参考文献28

  • 1Jemal A, Bray F, Center M M, et al. Global cancer statistics [J] . CA Cancer J Clin, 2011 ,61 (2) :69 - 90.
  • 2Calcagno AM, Salcido CD, Gillet J P, et al. Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics[J]. J Nat! Cancer Inst, 2010,102(21) :1637- 52.
  • 3Bhat-Nakshatri P, Appaiah H, Ballas C, et at. SLUG/SNAJ2 and tumor necrosis factor generate breast cells with CD44 + ICD24 - phenotype] n. BMC Cancer, 2010,10 :411.
  • 4AI-Hajj M, Wicha M S, Benito-Hernandez A. Prospective identification of tumorigenic breast cancer cells [J]. Proc Nat! Acad Sci USA, 2003,100(7) :3983 - 8.
  • 5Wright M H, Calcagno AM, Salcido CD, et at. Brcal breast tumors contain distinct CD44 + ICD24 - and CD133 + cells with cancer stem cell characteristics [J]. Breast Cancer Res, 2008, 10 (I):RIO.
  • 6Xu J X, Morii E, Liu Y, et at. High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells: high expression of CD55 as a novel character for side-population [J]. Exp Cell Res, 2007,313 (9) : 1877 - 85.
  • 7Pontier S M, Muller W J. Integrins in mammary-stern-cell biology and breast-cancer progression--a role in cancer stem cells [J]. J Cell Sci, 2009,122 (2) :207 -14.
  • 8Vaillant F, Asselin-Labat M L, Shackleton M, et al. The mammary progenitor marker CD6l1beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis [J]. Cancer Res, 2008,68(19) :7711 -7.
  • 9Croker A K, Goodale D, Chu J, et at. High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability [J]. J Cell Mol Med, 2009,13 (8B) :2236 - 52.
  • 10Hadnagy A, Gaboury L, Beaulieu R, et at. SP analysis may be used to identify cancer stem cell populations [J]. Exp Cell Res, 2006,312(19) :3701-10.

二级参考文献37

  • 1Cifuentes-Rojas C, Shippen D E. Telomerase regulation [ J ]. Mutat Res, 2012, 730(1-2):20-27.
  • 2Bekisz J, Baron S, Balinsky C, et al. Antiproliferative properties of type Ⅰ and type Ⅱ interferon [ J]. Pharmaceuticals (Basel), 2010, 3(4) :994-1015.
  • 3Daniel M, Peek G W , Tollefsbol T O. Regulation of the human catalytic subunit of telomerase [ J ]. Gene, 2012, 498 ( 2 ) : 135- 146.
  • 4Cristofari G, Adolf E, Reichenbach P, et al. Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation [ J]. Mol Cell, 2007, 27(6) : 882-889.
  • 5Gomez D E, Armando R G, Farina H G, et al. Telomere structure and telomerase in health and disease [ J]. Int J Oncol, 2012, 41(5) :1561-1569.
  • 6George J, Banik N L, Ray S K. Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines [ J]. Int J Biochem Cell Biol, 2010, 42(7) :1164-1173.
  • 7Song L L, Ponomareva L, Shen H, et al. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene [J]. PLoS One, 2010, 5(1):e8569-8578.
  • 8Horikawa I, Cable P L, Mazur S J, et al. Downstream E-Box- mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression [ J ]. Mol Biol Cell, 2002, 13($) :2585-2597.
  • 9Zhang Y, Chen L, Yang S, et al. E2FI: a potential negative regulator of hTERT transcription in normal cells upon activation of oncogenic c-Myc [ J]. Med Sci Monit, 2012, 18(1) :RA12-15.
  • 10Sicari B M, Troxell R, Salim F, et al. c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein [ J ]. Endocrinology, 2012, 153 ( 2 ) : 861-872.

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临床与实验病理学杂志
2014年 第3期

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