1Hato T, Tabata M, Oike Y. The role of angiopoietin-like proteins inangiogenesis and metabolism [J]. Trends Car- diovasc Med, 2008,18( 1 ):6-14.
2Kim I, Kim HG, Kim H, et al. Hepatic expression, synthe- sis and secretion of a novel fibrinogen/angiopoietin-relat-ed protein that prevents endothelial-cell apoptosis E J ]. Bio- chem J, 2000, 346: 603-610.
3Yoon JC, Chickering TW, Rosen ED, et al. Peroxisome pro- liferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation E J ]. Mol Cell Biol, 2000, 20(14) :5343-5349.
4Lei X, Shi F, Basu D,et al. Proteolytic processing of angio- poietin-like protein 4 by proproteinconvertases modulates its inhibitory effects on lipoprotein lipase activity [ J ]. J Bi- olChem, 2011,286(18):15747-15756.
5Cazes A, Galaup A, Chomel C, et al. Extracellular ma- trix-bound angiopoietin-like 4 inhibits endothelial cell ad- hesion, migration, and sprouting and alters actin cytoskele- ton[J]. Circ Res, 2006,99(11 ):1207-1215.
6Ge H, Yang G, Huang L, et al. Oligomerization and regu- lated proteolytic processing of angiopoietin-like protein 4 [J]. J BiolChem, 2004,279(3):2038-2045.
7Goh YY, Pal M, Chong HC, et al. Angiopoietin-like 4 inter- acts with integrins betal and beta5 to modulatekeratino- cyte migration[J]. Am J Pathol, 2010,177(6):2791-2803.
8Huang RL, Teo Z, Chong HC, et al. ANGPTL4 modulates vascular junction integrity by integrin signaling and disrup- tion of intercellular VE-cadherin and claudin-5 clusters [J]. Blood, 2011,118(14):3990-4002.
9Coussens LM, Werb Z. Inflammation and cancer[J]. Na- ture, 2002,420(6917):860-867.
10Legler DF, Bruckner M, Uetz-von AllmenE,et a/. Prosta- glandin E2 at new glance: novel insights in functional di- versity offer therapeutic chances [J]. Int J Biochem Cell Biol 2010,42 (2): 198-201.
2Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010 [J]. CA Cancer J Clin, 2010, 60: 277-300.
3Yau MH, Wang Y, Lam KS, et al. A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization[J]. J Biol Chem, 2009, 284(18): 11942-52.
4Le Jan S, Amy C, Cazes A, et al. Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma [J]. Am J Pathol, 2003, 162: 1521-8.
5Galaup A, Cazes A, Le Jan S, et al. Angiopoietin-like4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness [J]. Proc Natl Acad Sci USA, 2006, 103(49):18721-6.
6Padua D, Zhang XH, Wang Q, et al. TGF beta primes breast tumors for lung metastasis seeding through angiopoietin-like 4 [J]. Cell, 2008, 133(1): 66-77.
7Nakayama T, Hirakawa H, Shibata K, et al.Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion[J]. Oncol Rep, 2010, 24(3): 599-606.
8Shibata K, Nakayama T, Hirakawa H, et al. Clinicopathological significance of angiopoietin-like protein 4 expression in oesophageal squamous cell carcinoma[J]. J Clin Pathol, 2010, 63 (12): 1054-8.
9Nakayama T, Hirakawa H, Shibata K, et al. Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis [J]. Oncol Rep, 2011, 25(4): 929-35.
10Pollard TD, Cooper JA. Actin, a central player in cell shape and movement[J]. Science, 2009, 326(5957): 1208-12.
1Pulte D,Brenner H.Changes in survival in head and neck cancers in the late 20th and early 21st century:a period analysis[J].Oncologist,2010,15(9):994-1001.
2Rhodus NL.Management of oral complications from radiation and chemotherapy[J].Northwest Dent,2010,89(1):39-42.
3Nakayama T,Hirakawa H,Shibata K,et al.Expression of angiopoietin-like 4(ANGPTL4)in human colorectal cancer:ANGPTL4 promotes venous invasion and distant metastasis[J].Oncol Rep,2011,25(4):929-935.
4Zhang H,Wong CC,Wei H,et al.HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs[J].Oncogene,2012,31(14):1757-1770.
5Hattori N,Okochi-Takada E,Kikuyama M,et al.Methylation silencing of angiopoietin-like 4 in rat and human mammarycarcinomas[J].Cancer Sci,2011,102(7):1337-1343.
6Wang Z,Han B,Zhang Z,et al.Expression of angiopoietin-like 4and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma[J].Biomarkers,2010,15(1):39-46.
7Katanasaka Y,Kodera Y,Kitamura Y,et al.Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma[J].Mol Cancer,2013,12:31.
8He P,Borland MG,Zhu B,et al.Effect of ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta)in human lung cancer cell lines[J].Toxicology,2008,254(1-2):112-117.
9Girroir EE,Hollingshead HE,Billin AN,et al.Peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta)ligands inhibit growth of UACC903 and MCF7 human cancer cell lines[J].Toxicology,2008,243(1-2):236-243.