摘要
目的观察老年非小细胞肺癌患者凝血功能的变化及化疗对凝血功能的影响。方法分析2010年1月—2013年1月在本院接受治疗的老年肺癌患者(肺癌组)的临床资料,另选取40例老年健康体检者作为对照组。结果肺癌组共纳入43例,对照组40例。肺癌组PLT、PCT、PDW及MPV均显著高于对照组,差异有统计学意义(P<0.05)。肺癌组患者化疗后PT、TT、APTT、FIB、D-D、PC及FPS均显著低于化疗前,差异有统计学意义(P<0.05)。化疗结束后,肺癌组患者PT、TT及APTT呈现逐步升高的趋势。PT在化疗结束后第2、3及4周时显著高于化疗结束时(P<0.05);TT在化疗结束后第3、4周时显著高于化疗结束时(P<0.05);APPT在化疗结束后第3、4周时显著高于化疗结束时(P<0.05)。结论化疗能可逆性加剧老年肺癌患者本已存在的凝血功能亢进。
Objective To explore the change of coagulation function and the influence of chemotherapy on coagulation function in elderly patients with non-small cell lung cancer. Methods Clinical materials of elderly patients with non-small cell lung cancer were analyzed, and 40 healthy elderly people were collected and designed as control group. Results Levels of PLT, PCT, PDW and MPV in lung cancer group were significantly higher than the control group （ P 〈 0.05 ）. After chemotherapy, levels of PT, TT, APTT, FIB, D-D, PC and FPS in lung cancer group reduced significantly（P 〈 0.05）. After chemotherapy, levels of PT, TT and APTT in lung cancer group in- creased gradually. The level of PT at the time points of 2, 3 and 4 weeks after chemotherapy were significantly higher than those at the time point of 0 week after chemotherapy（ P 〈 0.05） ; the levels of TT and APTT at the time points of 3 and 4 weeks after chemotherapy were significantly higher than those at the time point of 0 week after chemotherapy（P 〈 0.05）. Conclusion Chemotherapy may aggravate the augmentation of coagulation function in elderly patients with non-small cell lung cancer.
出处
《实用临床医药杂志》
CAS
2014年第3期90-92,共3页
Journal of Clinical Medicine in Practice
关键词
非小细胞肺癌
老年
化疗
凝血功能
non-small cell lung cancer
elderly~ chemotherapy
coagulation function
