摘要
目的探讨C反应蛋白(CRP)、前白蛋白(PA)、白细胞(WBC)计数及分类在小儿急性上呼吸道感染鉴别诊断中的作用。方法选取125例上呼吸道感染患儿作为研究病例,根据临床症状和实验室检查结果将其分为细菌感染组(n=61)和病毒感染组(n=64)。另选取同期体检健康小儿60例作为对照组,对3组小儿的血液标本的血清CRP、PA水平及WBC计数和分类进行测定和分析。结果病毒感染组患儿与对照组小儿在血清CRP水平和PA水平方面比较无显著差异(P>0.05),而细菌感染组患儿的血清CRP水平显著高于病毒感染组和对照组(P<0.05),PA水平则显著低于病毒感染组和对照组(P<0.05);病毒感染组患儿与对照组小儿在WBC计数方面比较无显著差异(P>0.05),细菌感染组患儿的WBC计数显著高于病毒感染组和对照组(P<0.05),细菌感染组患儿的中性粒细胞比例显著高于对照组(P<0.05),且对照组小儿的中性粒细胞比例显著高于病毒感染组(P<0.05);病毒感染组患儿的淋巴细胞比例显著高于对照组(P<0.05),且对照组小儿的淋巴细胞比例显著高于细菌感染组(P<0.05)。结论血清CRP水平、WBC计数和中性粒细胞比例的升高以及PA水平的降低都可以作为诊断细菌性上呼吸道感染的参考依据,而淋巴细胞比例的上升可作为诊断病毒性上呼吸道感染的参考依据,临床医生应综合应用这些指标进行鉴别诊断以选择恰当的治疗措施。
Objectives To explore the role of C reactive protein（CRP）, prealbumin（PA）and white blood cell（WBC）count and classification in the differential diagnosisof children with infantile acute upper respiratory tract infection. Methods 125 children with upper respiratory tract infection were collected and divided into bacterial infection group（n= 61）and viral infection group（n= 64）according to the clinical symptoms and laboratory examination. 60 healthy children were selected and designed as control group. The serum CRP, PA levels and WBC count and classification were measured and analyzed among three groups. Results There were no significant differences of serum CRP level and PA level between the virus infection group and the control group（P 0.05）. The level of serum CRP in the bacterial infection group was significantly higher than that in the virusinfection group and the control group（P 0.05）,and the level of PA was significantly lower than that in the virus infection group and the control group（P 0.05）. There was no significant difference of WBC count between the virusinfection group and the control group（P0.05）. WBC count in the bacterial infection group was significantly higher than that in the virus infection group and the control group（P 0.05）. Percentage of neutrophils in the bacterial infection group was significantly higher than that in the control group（P 0.05）, and the percentageof neutrophils in the control group was significantly higher than that in the virus infection group（P 0.05）. Percentage of lymphocytes in the viral infection group was significantly higher than that in the control group（P 0.05）,and the percentage of lymphocytesin the control group was significantly higher than that in the bacterial infection group（P 0.05）. Conclusion Increasing of serum CRP level,WBC count,neutrophils percentage and declining of PA level can be used as the references for the diagnosisof the bacterial infection of the upper respiratory tract. Increasing of lymphocyte percentage can be used as the reference for the diagnosisof the viral infection of the upper respiratory tract.For the differential diagnosis,all these indicators should be considered comprehensively in order to formulate the proper therapeutic measures.
出处
《实用临床医药杂志》
CAS
2014年第1期49-52,共4页
Journal of Clinical Medicine in Practice
关键词
小儿上呼吸道感染
C反应蛋白
前白蛋白
白细胞计数和分类
infantile upper respiratory tract infection
C-reactive protein
prealbumin
WBC count and classification
