摘要
目的:观察左西孟旦对急性失代偿性心力衰竭患者心脏自主神经功能的影响。方法:收集2012-06至2013-01我院收治的急性失代偿性心力衰竭患者60例,按随机数字表格法分为观察组与对照组。对照组(n=30)采用基础抗心力衰竭治疗;观察组(n=30)在基础抗心力衰竭治疗上持续微泵注射左西孟旦注射液,行动态心电图检查,通过系统分析得出心率变异性的时域及频域分析指标。结果:观察组经左西孟旦治疗后心率变异性较对照组明显改善。全部窦性R-R间期的标准差(SDNN)、全部窦性R-R间期差值的均方根(RMSSD)、每5 min窦性R-R平均值的标准差(SDANN)、SDNN均值(SDNNI)及心率均得到明显改善(t分别为13.517、5.930、10.367和6.116,P<0.05)。频域指标低频(LF)、高频(HF)均得到明显改善(t分别为9.342和7.552,P<0.05),差异具有统计学意义。结论:左西孟旦可明显改善急性失代偿性心力衰竭患者的心率变异性。
Objective： To observe the impact of levosimendan on cardiac autonomic nervous function in patients with acute de- compensated heart failure （ADHF）. Methods： A total of 60 ADHF patients admitted in our hospital from 2012-06 to 2013-01were studied. The patients were divided into 2 groups, Observation group, in which the patients received anti-heart failure treatment plus levosimendan by sustained micro pump injection, and Control group, the patients received basic anti-heart failure treatment, n=30 in each group. The dynamic echocardiography was performed to examine the heart rate variability （HRV） in time domain and frequency domain analytical indicators in both groups. Results： Compared with Control group, the HRV was signifcantly improved in Observation group including all sinus RR interval standard deviation （SDNN）, all sinus RR interval difference （RMSSD）, every 5min sinus RR mean standard deviation （SDANN） and SDNN of mean （SDNNI）, t=13.517, 5.930, 10.367 and 6.116 respectively, all P〈0.05. The frequency domain of LF and HF were also improved in Observation group, t=-9.342 and 7.552, both P〈0.05. Conclusion： Levosimendan mav sipnificantlv imnrove HRV in ADHF patients.
出处
《中国循环杂志》
CSCD
北大核心
2014年第3期198-200,共3页
Chinese Circulation Journal
关键词
左西孟旦
急性失代偿性心力衰竭
心率变异性
持续微泵
Levosimendan
Acute de-compensated heart failure
Heart rate variability
Sustained micro pump
