摘要
目的观察清腑灌肠方保留灌肠对肝性脑病患者内毒素(LPS)、肿瘤坏死因子-α(TNF-α)和白介素6(IL-6)的影响。方法将72例肝性脑病患者分为治疗组38例和对照组34例,治疗组采用清腑灌肠方保留灌肠;对照组采用米醋灌肠。观察两组临床疗效以及治疗前后血氨、LPS、TNF-α和IL-6的变化。结果治疗组总有效率为89.47%,高于对照组的67.65%(P<0.05);两组治疗后血氨、LPS、TNF-α和IL-6比较,差异均有统计学意义(均P<0.05)。结论清腑灌肠方保留灌肠对肝性脑病有治疗作用,能降低肝性脑病患者血氨、LPS、TNF-α和IL-6水平。
Objective：To investigate the effect of Qingfuguanchang Decoction medicated by retention enema on serum LPS,TNF-α,and IL-6 level in patients with hepatic encephalopathy.Methods：72 cases of hepatic encephalopathy were divided into treatment group,38 cases and control group,34 cases.The treatment group was treated with Qingfuguanchang Decoction medicated by retention enema one time a day for 10 days and the control group was given vinegar enema respectively.The clinical efficacy and the change of serum blood ammonia,LPS,TNF-α,and IL-6 levels in the two groups were observed before and after treatment.Results：Comparing the clinical efficacy of the two groups,the difference was statistically significant （P＜ 0.05）.Comparing serum blood ammonia LPS,TNF-αt,and IL-6 levels before and after treatment,the differences were statistically significant （P＜ 0.05）.Conclusion：Qingfugumchang Decoction medicated by retention enema has a therapeutic effect on patients with hepatic encephalopathy,which can reduce the blood ammonia,LPS,TNF-αt and IL-6 levels.
出处
《中国中医急症》
2014年第3期389-390,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
浙江省温州市医药卫生科研项目基金(2010B052)
