摘要
目的 动态测定早产儿生后2周内粪便钙卫蛋白（fecal calprotectin,FC）水平,分析影响FC分泌的临床因素,探讨其在评价早产儿胃肠功能的价值.方法 2012年5-9月中国医科大学附属盛京医院新生儿科收治的胎龄≤32周或出生体重≤l 200g的早产儿47例,根据生后第7d的喂养情况分成喂养耐受组29例及喂养不耐受组18例.收集生后第1次胎便、第7d及第14 d最后一次粪便（以下依次简称为FC1、FC2和FC3）50-100 mg.用酶联免疫吸附法（ELASA）测定FC水平.结果 47例早产儿FC3水平明显高于FC1和FC2水平（P＜0.05）;FC1与FC2水平差异无统计学意义（P＞0.05）.母亲分娩前有产前感染的早产儿FC1水平明显高于无产前感染者（P＜0.05）.FC2水平与生后抗生素使用时间（d）呈显著负相关（r =-0.325,P＜0.05）.喂养不耐受组FC2水平明显低于喂养耐受组（P＜0.05）.喂养耐受组FC2、喂养不耐受组FC3水平分别与第7d和第14 d的肠道喂养量呈显著正相关（r =0.433,0.479,P＜0.05）.结论 产前感染及生后肠道喂养可促进早产儿胃肠道分泌FC,生后早期FC水平可反映早产儿早期胃肠道喂养情况,可作为评价早产儿生后早期消化道功能的无创性生物学指标.
Objective To determine the time course of fecal calprotectin （FC） excretion in preterm infants in the first two weeks of life and to identify influencing factors of FC levels.To explore whether FC may be an useful marker for the identification of gastrointestinal conditions in preterm infants.Methods FC concentration was measured using ELISA in 141 samples （50-100 mg）obtained from 47 preterm infants（gestational age less than 32 weeks or birth weight less than 1 200 grams）at birth,on day 7 and on day 14（The following was called FC1,FC2 and FC3 level for short）.Results FC3 level was significantly higher than FC1 and FC2 levels （P ＜0.05）,there were no significant differences between FC1 and FC2 levels in the 47 preterm infants（P ＞ 0.05）.The FC1 level in infants whose mothers had antenatal infection was significantly higher（P ＜ 0.05）.The FC2 level was negatively correlated with the antibiotic courses（r =-0.325,P ＜ 0.05）.The FC2 level in infants with feeding intolerance was significantly lower than that in infants with feeding tolerance（P ＜ 0.05）.The FC2 level in infants with feeding tolerance and the FC3 level in infants with feeding intolerance were positively correlated with the volume of enteral feeds,respectively （r =0.433,0.479,P ＜ 0.05）.Contusion Antenatal infection and postnatal enteral feeds may lead to an increase in the excretion of FC in preterm infants.FC level was associated with enteral feeding and may be a useful marker for evaluation of gastrointestinal function in preterm infants.
出处
《国际儿科学杂志》
2014年第2期198-201,共4页
International Journal of Pediatrics
关键词
钙结合蛋白
粪便
早产儿
肠道喂养
喂养不耐受
Calcium-binding proteins
Feces
Infant, Premature
Enteral nutrition
Feeding intolerance
